| Repair of joint erosions in rheumatoid arthritis: prevalence and patient characteristics in a large inception cohort. | |
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MedLine Citation:
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PMID: 19454405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Joint destruction in rheumatoid arthritis (RA) was until recently seen as an irreversible state. Lately, it was found that repair of bone erosions occurs; however, little is known about its prevalence. OBJECTIVE: To investigate the frequency of repair and patients' characteristics associated with repair in an inception cohort. PATIENTS AND METHODS: 250 patients with RA, included in the Leiden Early Arthritis Clinic between 1993 and 2000 and treated with conventional disease-modifying antirheumatic drugs, were studied (mean follow-up 10.1 years). Radiographs obtained annually were scored using the Sharp-van der Heijde method, initially aware of the chronology. Patients with a negative change in erosion scores on subsequent radiographs were selected and their series of radiographs were re-scored with concealed time sequence by three readers. Repair was defined as agreement between two readers of a negative change in erosion scores that persisted for at least 2 years. RESULTS: Repair was identified in 32 joints in 18 patients (7.2%). Patients with repair had a greater prevalence of autoantibodies (rheumatoid arthritis, anti-citrullinated protein antibody) and a higher level of joint destruction. In the joints with repair, arthritis was absent in the 2 years preceding repair. CONCLUSIONS: Repair occurred in 7.2% of the patients with RA, particularly in clinically inactive joints in patients with severe destructive disease. |
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Authors:
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Michael P M van der Linden; Ramona Boja; Naomi B Klarenbeek; Tom W J Huizinga; D?sir?e M van der Heijde; Annette H M van der Helm-van Mil |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-18 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 69 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-18 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 727-9 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands. M.P.M.van_der_Linden@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antirheumatic Agents / therapeutic use Arthritis, Rheumatoid / drug therapy, immunology, physiopathology*, radiography Autoantibodies / analysis Bone Regeneration / physiology* Disease Progression Female Follow-Up Studies Humans Male Middle Aged Remission Induction Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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