| Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine. | |
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MedLine Citation:
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PMID: 3948282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The removal of O6-methylguanine by human lymphoid cells corresponded, with certain assumptions, to a second-order chemical reaction in any given cell. There was a spectrum of proficiency in this respect for a considerable number of cells originating from different individuals and it was found that patients with diseases associated with autoimmunity tended to fall into the less proficient groups. E-B virus-induced lymphoid cell lines, derived from proficient, but not relatively deficient, peripheral blood lymphocytes, always (in 9/9 cases) reflected the level of proficiency of the donor lymphocytes with respect to removal of O6-methylguanine. Thus while proficient lymphocytes always produced proficient cell lines, deficient lymphocytes, in 3/8 cases, gave rise to more proficient cell lines. No evidence was found that groups of individuals exist who lack ability to remove 3-methyladenine from DNA, either from their blood lymphocytes or derived lymphoid cell lines. |
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Authors:
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P D Lawley; G Harris; E Phillips; W Irving; C B Colaço; P M Lydyard; I M Roitt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemico-biological interactions Volume: 57 ISSN: 0009-2797 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-04-11 Completed Date: 1986-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 107-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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analogs & derivatives*,
blood Autoimmune Diseases / blood, genetics Carcinogens / toxicity* Cell Line DNA Repair* Guanine / analogs & derivatives*, blood Humans Kinetics Lymphocytes / cytology, drug effects* Mathematics Models, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 20535-83-5/O-(6)-methylguanine; 5142-23-4/3-methyladenine; 73-24-5/Adenine; 73-40-5/Guanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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