Document Detail

Reovirus RNA transcriptase: evidence for a conformational change during activation of the core particle.
MedLine Citation:
PMID:  6206643     Owner:  NLM     Status:  MEDLINE    
Reovirus cores contain an RNA transcriptase capable of synthesizing messenger RNA. When cores are suspended in 1 X SSC at 37 degrees they are quiescent and synthesize no product, but in the presence of the components of an RNA transcriptase reaction mixture they actively synthesize mRNA. Photochemical crosslinking has been used to investigate the arrangement of RNA and protein in both "quiescent" and "active" cores. Irradiation induces the formation of a noncovalent RNA:protein complex in "quiescent" but not in "active" cores. This difference is attributed to a conformational change in the reovirus core which results from the transition between the "quiescent" and "active" states of the particle.
K F Powell; J D Harvey; A R Bellamy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virology     Volume:  137     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-10-12     Completed Date:  1984-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
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MeSH Terms
Enzyme Activation
Protein Conformation
RNA, Messenger / biosynthesis
RNA-Directed DNA Polymerase / metabolism*
Reoviridae / enzymology*
Ribonucleoproteins / metabolism
Reg. No./Substance:
0/RNA, Messenger; 0/Ribonucleoproteins; EC DNA Polymerase

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