Document Detail


Reorganization of the nuclear envelope during open mitosis.
MedLine Citation:
PMID:  18938243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the cytoplasm and constitutes a central component of intracellular architecture. During mitosis in metazoa, the NE breaks down leading to the complete mixing of the nuclear content with the cytosol. Interestingly, many NE components actively participate in mitotic progression. After chromosome segregation, the NE is reassembled around decondensing chromatin and the nuclear compartment is reestablished in the daughter cells. Here, we summarize recent progress in deciphering the molecular mechanisms underlying NE dynamics during cell division.
Authors:
Ulrike Kutay; Martin W Hetzer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-02
Journal Detail:
Title:  Current opinion in cell biology     Volume:  20     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-02-13     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  669-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
Cell Nucleus / metabolism*
Cytoplasm / metabolism
Endoplasmic Reticulum / metabolism
Humans
Mitosis / physiology*
Models, Biological
Nuclear Envelope / metabolism*
Nuclear Pore Complex Proteins / metabolism
Grant Support
ID/Acronym/Agency:
R01 GM073994/GM/NIGMS NIH HHS; R01 GM073994/GM/NIGMS NIH HHS; R01 GM073994-03/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Nuclear Pore Complex Proteins
Comments/Corrections

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