Document Detail


Reorganization of language-specific cortex in patients with lesions or mesial temporal epilepsy.
MedLine Citation:
PMID:  15557497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine brain activation profiles for receptive language function, using magnetoencephalography (MEG), in patients with left hemisphere space-occupying lesions and patients with left temporal lobe epilepsy due to mesial temporal sclerosis (MTS) and to evaluate whether cross- and intrahemispheric plasticity for language varied as a function of lesion type or location. METHODS: Twenty-one patients with MTS and 23 lesional patients underwent preoperative language mapping while performing a word recognition task. The anatomic location of late activity sources was determined by co-registering MEG coordinates onto structural MRI scans. A language laterality index was calculated based on the number of activity sources in each hemisphere. The location of language-specific activity was examined in relation to its proximity or overlap with Wernicke's area. RESULTS: A higher incidence of atypical language lateralization was noted among patients with MTS than lesional patients (43 vs 13%). The majority of MTS patients with early seizure onset (before age 5) showed atypical language lateralization. In contrast, the precise location of receptive language-specific cortex within the dominant hemisphere was found to be atypical (outside of Wernicke's area) in 30% of lesional patients and only 14% of MTS patients. CONCLUSIONS: There is an increased probability of a partial or total displacement of key components of the brain mechanism responsible for receptive language function to the nondominant hemisphere in mesial temporal sclerosis patients. Early onset of seizures is strongly associated with atypical language lateralization. Lesions in the dominant hemisphere tend to result in an intrahemispheric reorganization of linguistic function.
Authors:
E Pataraia; P G Simos; E M Castillo; R L Billingsley-Marshall; A L McGregor; J I Breier; S Sarkari; A C Papanicolaou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  63     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-08-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1825-32     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosurgery, Vivian L. Smith Center for Neurologic Research, University of Texas Medical Center at Houston, 1333 Moursund St., H 114, Houston, TX 77030, USA. epataraia1@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anterior Temporal Lobectomy
Atrophy
Brain Mapping / methods*
Child
Cohort Studies
Dominance, Cerebral / physiology*
Epilepsy, Temporal Lobe / physiopathology*,  surgery
Female
Humans
Language*
Language Tests
Magnetic Resonance Imaging
Magnetoencephalography
Male
Middle Aged
Neuronal Plasticity*
Pattern Recognition, Physiological
Preoperative Care
Retrospective Studies
Sclerosis / physiopathology
Temporal Lobe / pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
NS37941/NS/NINDS NIH HHS
Comments/Corrections
Comment In:
Neurology. 2004 Nov 23;63(10):1772-3   [PMID:  15557488 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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