| Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (Ventral caudal) in patients with dystonia. | |
| | |
MedLine Citation:
|
PMID: 10601454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A wide range of observations suggest that sensory inputs play a significant role in dystonia. For example, the map of the hand representation in the primary sensory cortex (area 3b) is altered in monkeys with dystonia-like movements resulting from overtraining in a gripping task. We investigated whether similar reorganization occurs in the somatic sensory thalamus of patients with dystonia (dystonia patients). We studied recordings of neuronal activity and microstimulation-evoked responses from the cutaneous core of the human principal somatic sensory nucleus (ventral caudal, Vc) of 11 dystonia patients who underwent stereotactic thalamotomy. Fifteen patients with essential tremor who underwent similar procedures were used as controls. The cutaneous core of Vc was defined as the part of the cellular thalamic region where the majority of cells had receptive fields (RFs) to innocuous cutaneous stimuli. The proportion of RFs including multiple parts of the body was greater in dystonia patients (29%) than in patients with essential tremor (11%). Similarly, the percentage of projected fields (PFs) including multiple body parts was higher in dystonia patients (71%) than in patients with essential tremor (41%). A match at a thalamic site was said to occur if the RF and PF at that site included a body part in common. Such matches were significantly less prevalent in dystonia patients (33%) than in patients with essential tremor (58%). The average length of the trajectory where the PF included a consistent, cutaneous RF was significantly longer in patients with dystonia than in control patients with essential tremor. The findings of sensory reorganization in Vc thalamus are congruent with those reported in the somatic sensory cortex of monkeys with dystonia-like movements resulting from overtraining in a gripping task. |
| | |
Authors:
|
F A Lenz; N N Byl |
Related Documents
:
|
8474484 - Nocturnal akathisia in parkinson's disease: treatment with clozapine. 2181074 - Controlled-release levodopa/benserazide (madopar hbs): clinical observations and levodo... 2458094 - Analgesic action of methylphenidate on parkinsonian sensory symptoms. mechanisms and pa... 22467084 - Articular involvement in ssc. 1457284 - Treatment of systemic sclerosis. 16504634 - Use of n-terminal prohormone brain natriuretic peptide assay for etiologic diagnosis of... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of neurophysiology Volume: 82 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 1999 Dec |
Date Detail:
|
Created Date: 2000-02-03 Completed Date: 2000-02-03 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 3204-12 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland 21287-7713, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age of Onset Brain Mapping Dystonia / pathology*, surgery Electric Stimulation Essential Tremor / pathology, physiopathology Humans Microelectrodes Neural Pathways / pathology, physiopathology Neuronal Plasticity / physiology Neurons, Afferent / pathology Neurosurgical Procedures Skin / innervation* Stereotaxic Techniques Ventral Thalamic Nuclei / pathology*, surgery |
| Grant Support | |
ID/Acronym/Agency:
|
K08-NS-1384/NS/NINDS NIH HHS; NS-28598/NS/NINDS NIH HHS; P01 NS-32386/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult a...
Next Document: Patterned activity in stratum lacunosum moleculare inhibits CA1 pyramidal neuron firing.