Document Detail


Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (Ventral caudal) in patients with dystonia.
MedLine Citation:
PMID:  10601454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A wide range of observations suggest that sensory inputs play a significant role in dystonia. For example, the map of the hand representation in the primary sensory cortex (area 3b) is altered in monkeys with dystonia-like movements resulting from overtraining in a gripping task. We investigated whether similar reorganization occurs in the somatic sensory thalamus of patients with dystonia (dystonia patients). We studied recordings of neuronal activity and microstimulation-evoked responses from the cutaneous core of the human principal somatic sensory nucleus (ventral caudal, Vc) of 11 dystonia patients who underwent stereotactic thalamotomy. Fifteen patients with essential tremor who underwent similar procedures were used as controls. The cutaneous core of Vc was defined as the part of the cellular thalamic region where the majority of cells had receptive fields (RFs) to innocuous cutaneous stimuli. The proportion of RFs including multiple parts of the body was greater in dystonia patients (29%) than in patients with essential tremor (11%). Similarly, the percentage of projected fields (PFs) including multiple body parts was higher in dystonia patients (71%) than in patients with essential tremor (41%). A match at a thalamic site was said to occur if the RF and PF at that site included a body part in common. Such matches were significantly less prevalent in dystonia patients (33%) than in patients with essential tremor (58%). The average length of the trajectory where the PF included a consistent, cutaneous RF was significantly longer in patients with dystonia than in control patients with essential tremor. The findings of sensory reorganization in Vc thalamus are congruent with those reported in the somatic sensory cortex of monkeys with dystonia-like movements resulting from overtraining in a gripping task.
Authors:
F A Lenz; N N Byl
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  82     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3204-12     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland 21287-7713, USA.
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Brain Mapping
Dystonia / pathology*,  surgery
Electric Stimulation
Essential Tremor / pathology,  physiopathology
Humans
Microelectrodes
Neural Pathways / pathology,  physiopathology
Neuronal Plasticity / physiology
Neurons, Afferent / pathology
Neurosurgical Procedures
Skin / innervation*
Stereotaxic Techniques
Ventral Thalamic Nuclei / pathology*,  surgery
Grant Support
ID/Acronym/Agency:
K08-NS-1384/NS/NINDS NIH HHS; NS-28598/NS/NINDS NIH HHS; P01 NS-32386/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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