| Reorganization of the cerebro-cerebellar network of language production in patients with congenital left-hemispheric brain lesions. | |
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MedLine Citation:
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PMID: 18158178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with congenital lesions of the left cerebral hemisphere may reorganize language functions into the right hemisphere. In these patients, language production is represented homotopically to the left-hemispheric language areas. We studied cerebellar activation in five patients with congenital lesions of the left cerebral hemisphere to assess if the language network is reorganized completely in these patients, i.e. including also cerebellar language functions. As compared to a group of controls matched for age, sex, and verbal IQ, the patients recruited an area not in the right but in the left cerebellar hemisphere. The extent of laterality of the cerebellar activation correlated significantly with the laterality of the frontal activation. We suggest that the developing brain reacts to early focal lesions in the left hemisphere with a mirror-image organization of the entire cerebro-cerebellar network engaged in speech production. |
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Authors:
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K Lidzba; M Wilke; M Staudt; I Krägeloh-Mann; W Grodd |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2007-12-26 |
Journal Detail:
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Title: Brain and language Volume: 106 ISSN: 1090-2155 ISO Abbreviation: Brain Lang Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-02 Completed Date: 2008-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506220 Medline TA: Brain Lang Country: United States |
Other Details:
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Languages: eng Pagination: 204-10 Citation Subset: IM |
Affiliation:
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Department of Developmental Neurology, University Children's Hospital, Hoppe-Seyler-Str. 1, Tübingen 72076, Germany. Karen.lidzba@med.uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cerebellum / pathology, physiopathology Cerebral Cortex / pathology, physiopathology Cerebrum / pathology, physiopathology* Dominance, Cerebral / physiology* Female Frontal Lobe / pathology, physiopathology Functional Laterality / physiology Humans Infarction, Middle Cerebral Artery / congenital, pathology, physiopathology* Language* Language Development Disorders / diagnosis, physiopathology*, psychology Language Tests Magnetic Resonance Imaging Male Neuronal Plasticity / physiology Neurons / physiology Neuropsychological Tests Task Performance and Analysis |
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