Document Detail

Reorganization of the cerebro-cerebellar network of language production in patients with congenital left-hemispheric brain lesions.
MedLine Citation:
PMID:  18158178     Owner:  NLM     Status:  MEDLINE    
Patients with congenital lesions of the left cerebral hemisphere may reorganize language functions into the right hemisphere. In these patients, language production is represented homotopically to the left-hemispheric language areas. We studied cerebellar activation in five patients with congenital lesions of the left cerebral hemisphere to assess if the language network is reorganized completely in these patients, i.e. including also cerebellar language functions. As compared to a group of controls matched for age, sex, and verbal IQ, the patients recruited an area not in the right but in the left cerebellar hemisphere. The extent of laterality of the cerebellar activation correlated significantly with the laterality of the frontal activation. We suggest that the developing brain reacts to early focal lesions in the left hemisphere with a mirror-image organization of the entire cerebro-cerebellar network engaged in speech production.
K Lidzba; M Wilke; M Staudt; I Krägeloh-Mann; W Grodd
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-12-26
Journal Detail:
Title:  Brain and language     Volume:  106     ISSN:  1090-2155     ISO Abbreviation:  Brain Lang     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-02     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506220     Medline TA:  Brain Lang     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-10     Citation Subset:  IM    
Department of Developmental Neurology, University Children's Hospital, Hoppe-Seyler-Str. 1, Tübingen 72076, Germany.
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MeSH Terms
Cerebellum / pathology,  physiopathology
Cerebral Cortex / pathology,  physiopathology
Cerebrum / pathology,  physiopathology*
Dominance, Cerebral / physiology*
Frontal Lobe / pathology,  physiopathology
Functional Laterality / physiology
Infarction, Middle Cerebral Artery / congenital,  pathology,  physiopathology*
Language Development Disorders / diagnosis,  physiopathology*,  psychology
Language Tests
Magnetic Resonance Imaging
Neuronal Plasticity / physiology
Neurons / physiology
Neuropsychological Tests
Task Performance and Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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