| Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation. | |
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MedLine Citation:
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PMID: 20870879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The organization and control of polarized growth through the cell cycle of Schizosaccharomyces pombe, a single-celled eukaryote, have been studied extensively. We have investigated the changes in these processes when S. pombe differentiates to form multicellular invasive mycelia and have found striking alterations to the behavior of some of the key regulatory proteins. Cells at the tips of invading filaments are considerably more elongated than cells growing singly and grow at one pole only. The filament tip follows a strict direction of growth through multiple cell cycles. A group of proteins involved in the growth process and actin regulation, comprising Spo20, Bgs4, activated Cdc42, and Crn1, are all concentrated at the growing tip, unlike their distribution at both ends of single cells. In contrast, several proteins implicated in microtubule-dependent organization of growth, including Tea1, Tea4, Mod5, and Pom1, all show the opposite effect and are relatively depleted at the growing end and enriched at the nongrowing end, although Tea1 appears to continue to be delivered to both ends. A third group acting at different stages of the cell cycle, including Bud6, Rga4, and Mid1, localize similarly in filaments and single cells, while Nif1 shows a reciprocal localization to Pom1. |
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Authors:
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James Dodgson; William Brown; Carlos A Rosa; John Armstrong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-24 |
Journal Detail:
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Title: Eukaryotic cell Volume: 9 ISSN: 1535-9786 ISO Abbreviation: Eukaryotic Cell Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2011-02-23 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101130731 Medline TA: Eukaryot Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1788-97 Citation Subset: IM |
Affiliation:
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University of Sussex, Falmer, Brighton, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gene Deletion Genes, Fungal Microtubule-Associated Proteins / genetics, metabolism Mycelium / growth & development, metabolism Schizosaccharomyces / cytology, genetics, growth & development*, metabolism Schizosaccharomyces pombe Proteins / genetics, metabolism Species Specificity Time-Lapse Imaging |
| Grant Support | |
ID/Acronym/Agency:
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G0400062//Medical Research Council; //Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Microtubule-Associated Proteins; 0/Schizosaccharomyces pombe Proteins; 0/Tea1 protein, S pombe |
| Comments/Corrections | |
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