Document Detail

Reopening of internal carotid artery occlusions during heparin-induced LDL precipitation (H.E.L.P.) associated with improved haemorheology: report of 2 cases.
MedLine Citation:
PMID:  8333205     Owner:  NLM     Status:  MEDLINE    
As has already been reported, there is a direct relationship between the severity of cerebrovascular insufficiency and elevated plasma fibrinogen levels, as well as whole blood and plasma viscosity, Red Cell Transit Time (RCTT) and cerebral blood flow. By applying heparin-induced extracorporeal LDL < cholesterol, triglycerides, fibrinogen > precipitation (H.E.L.P.), a rapid reduction of fibrinogen has become possible which has proved to be very beneficial for the treatment of acute stroke and multi-infarct disease. The present report demonstrates the impact of H.E.L.P. in connection with Doppler and Duplex sonography: In one patient a complete occlusion at the origin of the right internal carotid artery was revealed by Doppler and Duplex sonography. In a second patient, a complete occlusion of the left internal carotid artery was verified. By applying H.E.L.P. once a week (seven times in patient #1, twelve times in patient #2), a consistent lowering of fibrinogen, whole blood and plasma viscosity, red cell transit time, total cholesterol, low density lipoprotein, lipoprotein (a) and triglycerides was achieved. After H.E.L.P. application, Doppler/Duplex sonography showed complete reopening of the previously occluded vessel in patient #1 and patency of the vessel of patient #2.
M Walzl; K Niederkorn; B Walzl; S Horner; H Lechner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  105     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-16     Completed Date:  1993-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  350-4     Citation Subset:  IM    
Department of Neurology, Karl-Franzens University of Graz.
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MeSH Terms
Brain Ischemia / blood,  therapy,  ultrasonography
Carotid Artery, Internal / ultrasonography
Carotid Stenosis / blood,  therapy*
Cholesterol, LDL / blood
Extracorporeal Circulation / instrumentation*
Fibrinogen / metabolism
Heparin / administration & dosage*
Lipoprotein(a) / blood
Lipoproteins, LDL / blood*
Middle Aged
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, LDL; 0/Lipoprotein(a); 0/Lipoproteins, LDL; 0/Triglycerides; 9001-32-5/Fibrinogen; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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