Document Detail


Renovascular hypertension: treatment with the oral angiotensin-converting enzyme inhibitor enalapril.
MedLine Citation:
PMID:  3017107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixteen patients with an established diagnosis of renovascular hypertension were entered in an open study of enalapril (MK421), an oral angiotensin-converting enzyme (ACE) inhibitor, for treatment of their hypertension. Initial blood pressure was 178.9 +/- 6.3/106.2 +/- 3.1 mm Hg during conventional therapy on a median of 3 different antihypertensive agents. All antihypertensive therapy was ceased and the patients admitted to hospital. Following introduction of enalapril, blood pressure fell to 161.5 +/- 6.9/90.6 +/- 4.1 mm Hg at 24 h (p less than 0.01 systolic and diastolic). Blood pressure control (diastolic blood pressure, phase V, less than 95 mm Hg) was achieved with monotherapy in 7 patients and in a further 5 patients with addition of a diuretic. Renal function was compromised in 4 patients, requiring cessation of enalapril in 2 instances. Enalapril is an oral ACE inhibitor useful in the treatment of renovascular hypertension. Close monitoring of renal function is necessary during the introduction of enalapril therapy in patients with renovascular hypertension.
Authors:
B Jackson; B F Murphy; C I Johnston; P Kincaid-Smith; J A Whitworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of nephrology     Volume:  6     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  182-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Creatinine / blood
Drug Evaluation
Enalapril / therapeutic use*
Female
Humans
Hypertension, Renovascular / drug therapy*
Male
Middle Aged
Chemical
Reg. No./Substance:
60-27-5/Creatinine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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