Document Detail

Renoprotective effect of mannitol infusion during extracorporeal shock lithotripsy.
MedLine Citation:
PMID:  19526157     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the role of mannitol infusion in preventing or ameliorating renal injury that accompanies shock wave lithotripsy as measured by changes in resistive index (RI). METHODS: Between February and September 2006, 38 patients (28 men and 10 women) underwent extracorporeal shock wave lithotripsy (ESWL) for radiologically documented renal stones in The Surgical Specialties Hospital ESWL unit, Baghdad, Iraq. The 38 patients aged 20-50 years with renal stones of 10-20 mm size, scheduled for ESWL therapy, were divided into a control group (20 patients) and mannitol group (treatment group of 18 patients). All patients had their renal RI measured before ESWL, immediately after ESWL, then 3 and 7 days later. While patients in the mannitol group were given 0.5 gm/kg mannitol infusion during lithotripsy, the control group patients were given nothing. Changes in renal RI in both groups were evaluated statistically within the group and between the 2 groups. RESULTS: A significant rise in renal RI was found in the control group immediately after ESWL, then 3 and 7 days after. It increased from an initial value of 0.5875 to 0.6500, 0.6300, and 0.6245. The mannitol group showed fewer changes, yet still significant from 0.5850 to 0.6061, 0.6022, and 0.5967. This elevation of renal RI in the control group when compared to the mannitol group was statistically significant. CONCLUSION: Mannitol has a renoprotective function when given during ESWL, as evidenced by the statistically significant reduction in renal RI.
Samir A Muter; Usama N Rifat; Ziad H Abd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  30     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  767-70     Citation Subset:  IM    
Department of Urology, Medical City Hospital, Baghdad, Iraq.
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MeSH Terms
Case-Control Studies
Kidney / drug effects*
Lithotripsy / adverse effects*
Mannitol / administration & dosage*,  pharmacology
Middle Aged
Reg. No./Substance:

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