Document Detail


Renoprotective effect of Spirulina fusiformis on cisplatin-induced oxidative stress and renal dysfunction in rats.
MedLine Citation:
PMID:  16703798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cisplatin is an effective chemotherapeutic agent used in the treatment of a wide array of both pediatric and adult malignancies. Dose-dependent and cumulative nephrotoxicity is the major toxicity of this compound, sometimes requiring a reduction in dose or discontinuation of treatment. Recent evidences have implicated oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Spirulina fusiformis, blue-green algae, is claimed to be a potential antioxidant. The present study was designed to explore the renoprotective potential of Spirulina fusiformis against cisplatin-induced oxidative stress and renal dysfunction. Spirulina fusiformis (500,1000,1500 mg/kg(-1) p.o.) was administered 2 days before and until 3 days after cisplatin challenge (5 mg/kg(-1) i.p.). Renal injury was assessed by measuring serum creatinine, blood urea nitrogen, creatinine and urea clearance, and serum nitrite levels. Renal oxidative stress was determined by renal TBARS levels, reduced glutathione levels, and by enzymatic activity of superoxide dismutase and catalase. A single dose of cisplatin produced marked renal oxidative and nitrosative stress and significantly deranged renal functions. Chronic Spirulina fusiformis treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation, and enhanced reduced glutathione levels, superoxide dismutase, and catalase activities. The results of the present study clearly demonstrate the pivotal role of reactive oxygen species and their relation to renal dysfunction and point to the therapeutic potential of Spirulina fusiformis in cisplatin-induced nephrotoxicity.
Authors:
Anurag Kuhad; Naveen Tirkey; Sangeeta Pilkhwal; Kanwaljit Chopra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  28     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-11-30     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Affiliation:
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cisplatin / adverse effects*
Female
Kidney Diseases / chemically induced*,  prevention & control*
Male
Oxidative Stress / drug effects*
Rats
Rats, Wistar
Spirulina / physiology*
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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