Document Detail


Renojejunal reflex controlling jejunal absorption of fluid and NaCl.
MedLine Citation:
PMID:  1527353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to elucidate renojejunal reflex controlling the net jejunal fluid, Na+, and Cl- absorption in response to an increased ureteropelvic pressure (UPP) in anesthetized dogs. Unilateral UPP was increased under hydrostatic pressure from 0 to 80 mmHg by a step of 20 mmHg in random order, while the contralateral UPP was maintained at around 0 mmHg. The net absorption of fluid, Na+, and Cl- decreased in proportion to increased UPP. At a UPP of 0 mmHg, the net jejunal fluid, Na+, and Cl- absorption were 11.1 +/- 0.4 ml, 2.48 +/- 0.07, and 1.98 +/- 0.05 mEq, and significantly decreased to 7.38 +/- 0.6 ml, 2.11 +/- 0.15, and 1.68 +/- 0.13 mEq by an increase of UPP to 40 mmHg, respectively. An increase of bilateral UPP up to 40 mmHg or more occlusively depressed the absorption. These responses were blocked by renal denervation and by administration of atropine but not by yohimbine. These results indicate that the increase of UPP decreases jejunal fluid, Na+, and Cl- absorption (renojejunal reflex), and that the afferent and efferent limbs of this reflex are the renal nerves and cholinergic fibers. This renojejunal reflex might play an important role in body fluid homeostasis under the pathological condition.
Authors:
S Suzuki; M R Khanchowdhury; N Uemura; H Morita; H Hosomi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  39     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  219-27     Citation Subset:  IM    
Affiliation:
Department of Physiology, Kagawa Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Denervation
Dogs
Female
Hemodynamics
Hydrostatic Pressure
Intestinal Absorption
Jejunum / metabolism*
Kidney Pelvis / physiology*
Male
Neurons, Afferent / drug effects
Reflex / physiology
Sodium Chloride / pharmacokinetics*
Ureter / physiology*
Yohimbine / pharmacology
Chemical
Reg. No./Substance:
146-48-5/Yohimbine; 51-55-8/Atropine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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