Document Detail


Reninoma: case report and literature review.
MedLine Citation:
PMID:  18192852     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients. The subject had persistent elevation of both plasma renin activity (PRA) and aldosterone. Imaging studies revealed the presence of a lesion in the renal cortex, which was further identified as a renin-producing lesion via selective venous catheterization following administration of an angiotensin-converting enzyme inhibitor (ACE-I). Following partial nephrectomy, the PRA and plasma aldosterone levels declined rapidly and the blood pressure and potassium supplementation requirements normalized. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis.
Authors:
Lara Wong; Thomas H S Hsu; Mark G Perlroth; Lawrence V Hofmann; Claudia M Haynes; Laurence Katznelson
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  26     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  IM    
Affiliation:
Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Hyperaldosteronism / etiology*
Hypertension / etiology*,  surgery
Juxtaglomerular Apparatus / cytology,  pathology*
Kidney Neoplasms / complications*,  pathology,  surgery
Nephrectomy
Renin / metabolism*
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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