Document Detail


Renin release.
MedLine Citation:
PMID:  17928544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the entrance of the glomerular capillary network. It has been known for a long time that renin synthesis and secretion are stimulated by the sympathetic nerves and the prostaglandins and are inhibited in negative feedback loops by angiotensin II, high blood pressure, salt, and volume overload. In contrast, the events controlling the function of renin-secreting cells at the organ and cellular level are markedly less clear and remain mysterious in certain aspects. The unravelling of these mysteries has led to new and interesting insights into the process of renin release.
Authors:
Frank Schweda; Ulla Friis; Charlotte Wagner; Ole Skott; Armin Kurtz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiology (Bethesda, Md.)     Volume:  22     ISSN:  1548-9213     ISO Abbreviation:  Physiology (Bethesda)     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2008-01-16     Revised Date:  2010-01-14    
Medline Journal Info:
Nlm Unique ID:  101208185     Medline TA:  Physiology (Bethesda)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-9     Citation Subset:  IM    
Affiliation:
Institute of Physiology, University of Regensburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclic AMP / metabolism
Humans
Juxtaglomerular Apparatus / cytology,  metabolism,  secretion
Kidney / cytology,  metabolism,  secretion
Paracrine Communication / physiology
Protein Processing, Post-Translational / physiology*
Renin / biosynthesis*,  secretion*
Secretory Vesicles / metabolism
Signal Transduction / physiology
Chemical
Reg. No./Substance:
60-92-4/Cyclic AMP; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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