Document Detail

Renin and prorenin as biomarkers in hypertension.
MedLine Citation:
PMID:  22820372     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review examines the evidence that plasma renin and/or prorenin level may be used to guide therapy in hypertension and as an independent risk factor for future cardiovascular events.
RECENT FINDINGS: A large number of retrospective analyses of patient populations in clinical trials, in whom 'baseline' renin measurements were available, supports that high renin, but not high prorenin levels, are indicative of future cardiovascular disease and death, particularly in patients with kidney dysfunction and/or hypertension. The relationship is not affected by the use of renin-angiotensin system (RAS) blockers. High renin levels also tend to support the use of RAS inhibitors as first-choice antihypertensive agents. However, the added value of a renin measurement on top of traditional risk factors is modest, and the pressure response to RAS blockade, even in high-renin patients, varies widely.
SUMMARY: Measuring 'baseline' renin as a marker of future cardiovascular events or to determine the choice of drug is of limited value in an individual patient.
A H Jan Danser
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  21     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-09     Completed Date:  2013-01-03     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  508-14     Citation Subset:  IM    
Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Biological Markers / blood
Hypertension / blood*,  drug therapy,  physiopathology
Renin / blood*,  metabolism
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Biological Markers; EC

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