Document Detail


Renin inhibition.
MedLine Citation:
PMID:  8573547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these peptide-related compounds. Peptidomimetic renin inhibitors that have been stabilized to enzymatic degradation in conjunction with optimizing physical characteristics amenable to intestinal absorption offer the greatest promise to date. Studies in animal models demonstrate that renin inhibitors are capable of reducing both systolic and diastolic blood pressures without causing reflex tachycardia. The response appears to be sustained with chronic administration. The beneficial cardiovascular effects of these compounds have been confirmed in the few studies conducted in patients with hypertension and in those with congestive heart failure. Further development of renin inhibitors is warranted.
Authors:
H D Kleinert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  9     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-12     Completed Date:  1996-03-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  645-55     Citation Subset:  IM    
Affiliation:
Abbott Laboratories, Abbott Park, IL 60064, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antihypertensive Agents / pharmacology*
Biological Availability
Heart Failure / drug therapy
Hemodynamics / drug effects
Humans
Hypertension / drug therapy
Intestinal Absorption / drug effects
Molecular Sequence Data
Renin / antagonists & inhibitors*,  chemistry,  metabolism
Renin-Angiotensin System / drug effects*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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