Document Detail


Renin inhibition: a new approach to cardiovascular therapy.
MedLine Citation:
PMID:  7983230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The renin-angiotensin system (RAS) functions as a primary regulator in the short-term and long-term control of blood pressure. Pharmacologic inhibition of the RAS with angiotensin-converting enzyme (ACE) inhibition is effective for treating systemic hypertension and congestive heart failure. As a more specific therapy, the development of renin inhibitors has evolved through various approaches: specific renin antibodies, peptides developed from prosegments of renin precursor, oligopeptides related to pepstatin a universal inhibitor of aspartyl proteinase enzyme, and analogs of angiotensinogen (the renin substrate). Angiotensinogen analogs are promising as therapeutic agents because of high potency, metabolic stability, and good oral bioavailability. Ongoing research is directed towards the application of renin inhibition, the treatment of various cardiovascular disorders, and as a biological probe for understanding the role of the RAS in control of blood pressure and blood volume.
Authors:
W H Frishman; A Fozailoff; C Lin; C Dike
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  34     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-04     Completed Date:  1995-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  873-80     Citation Subset:  IM    
Affiliation:
Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
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MeSH Terms
Descriptor/Qualifier:
Amides / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Heart Failure / drug therapy*
Humans
Hypertension / drug therapy*
Imidazoles / pharmacology
Morpholines / pharmacology
Pharmacology, Clinical
Piperazines / pharmacology
Renin / antagonists & inhibitors*
Renin-Angiotensin System / drug effects*
Thiazoles / pharmacology
Chemical
Reg. No./Substance:
0/Amides; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazoles; 0/Morpholines; 0/Piperazines; 0/Thiazoles; 130316-95-9/A 74273; 135669-48-6/remikiren; 138742-43-5/zankiren hydrochloride; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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