| Renin inhibition: a new approach to cardiovascular therapy. | |
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MedLine Citation:
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PMID: 7983230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin system (RAS) functions as a primary regulator in the short-term and long-term control of blood pressure. Pharmacologic inhibition of the RAS with angiotensin-converting enzyme (ACE) inhibition is effective for treating systemic hypertension and congestive heart failure. As a more specific therapy, the development of renin inhibitors has evolved through various approaches: specific renin antibodies, peptides developed from prosegments of renin precursor, oligopeptides related to pepstatin a universal inhibitor of aspartyl proteinase enzyme, and analogs of angiotensinogen (the renin substrate). Angiotensinogen analogs are promising as therapeutic agents because of high potency, metabolic stability, and good oral bioavailability. Ongoing research is directed towards the application of renin inhibition, the treatment of various cardiovascular disorders, and as a biological probe for understanding the role of the RAS in control of blood pressure and blood volume. |
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Authors:
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W H Frishman; A Fozailoff; C Lin; C Dike |
Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 34 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-01-04 Completed Date: 1995-01-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 873-80 Citation Subset: IM |
Affiliation:
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Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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pharmacology Angiotensin-Converting Enzyme Inhibitors / pharmacology* Heart Failure / drug therapy* Humans Hypertension / drug therapy* Imidazoles / pharmacology Morpholines / pharmacology Pharmacology, Clinical Piperazines / pharmacology Renin / antagonists & inhibitors* Renin-Angiotensin System / drug effects* Thiazoles / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazoles; 0/Morpholines; 0/Piperazines; 0/Thiazoles; 130316-95-9/A 74273; 135669-48-6/remikiren; 138742-43-5/zankiren hydrochloride; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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