Document Detail

Renin: friend or foe?
MedLine Citation:
PMID:  17488768     Owner:  NLM     Status:  MEDLINE    
Renin maintains blood pressure through vasoconstriction when there is inadequate salt to maintain volume. In populations where blood pressure is more often high than low, and vascular death more common than haemorrhage or dehydration, therapeutic reductions in renin secretion or response are valuable. Whether long-term benefits are due entirely to blood pressure reduction remains unproved. The pathway can be blocked at its rate-limiting step (beta blockade or direct renin inhibition), the synthesis of the active product, angiotensin II, or at the receptor for angiotensin. Because renin and sodium are the two main factors in blood pressure control, and renin levels vary inversely with sodium load, blood pressure control requires a combination of natriuresis and blocking the consequential increase in renin activity. Being a large and stable molecule, renin is among the easiest and cheapest of hormone measurements. Understanding the simple biochemistry and physiology of renin permits optimal use of the drugs acting to raise or suppress this hormone.
Morris J Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-05-08
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  93     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-10-04     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1026-33     Citation Subset:  AIM; IM    
Clinical Pharmacology Unit, Addenbrookes Hospital, Cambridge, UK.
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MeSH Terms
Antihypertensive Agents / pharmacology
Blood Pressure / physiology
Practice Guidelines as Topic
Renin / antagonists & inhibitors,  blood,  physiology*
Renin-Angiotensin System / drug effects,  physiology
Reg. No./Substance:
0/Antihypertensive Agents; EC

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