| Renin: at the heart of the mast cell. | |
| | |
MedLine Citation:
|
PMID: 17498056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiac mast cells proliferate in cardiovascular diseases. In myocardial ischemia, mast cell mediators contribute to coronary vasoconstriction, arrhythmias, leukocyte recruitment, and tissue injury and repair. Arrhythmic dysfunction, coronary vasoconstriction, and contractile failure are also characteristic of cardiac anaphylaxis. In coronary atherosclerosis, mast cell mediators facilitate cholesterol accumulation and plaque destabilization. In cardiac failure, mast cell chymase causes myocyte apoptosis and fibroblast proliferation, leading to ventricular dysfunction. Chymase and tryptase also contribute to fibrosis in cardiomyopathies and myocarditis. In addition, mast cell tumor necrosis factor-alpha promotes myocardial remodeling. Cardiac remodeling and hypertrophy in end-stage hypertension are also induced by mast cell mediators and proteases. We recently discovered that cardiac mast cells contain and release renin, which initiates local angiotensin formation. Angiotensin causes coronary vasoconstriction, arrhythmias, fibrosis, apoptosis, and endothelin release, all demonstrated mechanisms of mast-cell-associated cardiac disease. The effects of angiotensin are further amplified by the release of norepinephrine from cardiac sympathetic nerves. Our discovery of renin in cardiac mast cells and its release in pathophysiological conditions uncovers an important new pathway in the development of mast-cell-associated heart diseases. Several steps in this novel pathway may constitute future therapeutic targets. |
| | |
Authors:
|
Alicia C Reid; Randi B Silver; Roberto Levi |
Related Documents
:
|
20410616 - Tongue muscle-derived stem cells express connexin 43 and improve cardiac remodeling and... 19536376 - The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardiu... 11566936 - Cardioreparation in hypertensive heart disease. 18678406 - The effect of polypyrrole on arteriogenesis in an acute rat infarct model. 12822746 - Electroanatomic mapping of endocardial right ventricular activation as a guide for cath... 17075376 - Fast-track failure after cardiac surgery: development of a prediction model. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Immunological reviews Volume: 217 ISSN: 0105-2896 ISO Abbreviation: Immunol. Rev. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-05-14 Completed Date: 2007-07-16 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
|
Languages: eng Pagination: 123-40 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10021, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiovascular Diseases / immunology Heart Humans Mast Cells / immunology* Myocardium / immunology* Renin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
DK60726/DK/NIDDK NIH HHS; HL34215/HL/NHLBI NIH HHS; HL46403/HL/NHLBI NIH HHS; HL47073/HL/NHLBI NIH HHS; HL73400/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mast cells: multipotent local effector cells in atherothrombosis.
Next Document: Mast cell tryptases and chymases in inflammation and host defense.