Document Detail

Renin-angiotensin system and stroke.
MedLine Citation:
PMID:  18690518     Owner:  NLM     Status:  MEDLINE    
The renin-angiotensin system (RAS) is a major regulatory system of cardiovascular and renal function. Many new aspects of this system have been revealed in recent years, leading to new therapeutic approaches. It's well known that RAS blocking agents have potent antiatherosclerotic effects, which are mediated by their antihypertensive, anti-inflammatory, antiproliferative, and oxidative stress lowering properties. Inhibitors of RAS are now first-line treatments for hypertensive target organ damage. Their effects are greater than expected by their ability to lower blood pressure. Angiotensin receptor blockers reduce the frequency of atrial fibrillation and stroke, are also able to prevent cardiovascular and renal events in diabetic patients. Thus, blockade of RAS represents one of the most important strategies in order to reduce cardiovascular risk.
Simona Marcheselli; Giuseppe Micieli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  29 Suppl 2     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S277-8     Citation Subset:  IM    
Neurologia I e Stroke Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Italy.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology,  therapeutic use
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Angiotensins / antagonists & inhibitors*,  metabolism
Atrial Fibrillation / drug therapy,  physiopathology,  prevention & control
Cerebrovascular Circulation / drug effects*,  physiology
Receptors, Angiotensin / antagonists & inhibitors*,  metabolism
Renin-Angiotensin System / drug effects*,  physiology*
Stroke / metabolism,  physiopathology*,  prevention & control*
Vasodilator Agents / pharmacology,  therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Angiotensins; 0/Receptors, Angiotensin; 0/Vasodilator Agents

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