Document Detail


Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats.
MedLine Citation:
PMID:  2143633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have recently shown that the octapeptide angiotensin II is a potent stimulus of protein synthesis and growth in cultured cardiomyocytes. The present study was performed to determine if the renin-angiotensin system was involved in regulating cardiac cell growth in vivo. The pressure-overload cardiac hypertrophy model that develops in abdominal aorta-constricted rats was studied. At 7 and 15 days after abdominal aorta constriction, rats developed significant left ventricular hypertrophy. The increase in left ventricular mass was completely prevented in animals fed the angiotensin-converting enzyme inhibitor, enalapril maleate (0.2 mg/ml) in their drinking water. Cardiac afterload was the same in both groups of animals in that carotid artery pressures were not different in conscious awake aortic-constricted animals receiving and not receiving enalapril. These data suggest a direct growth effect of angiotensin II on the left ventricle and indicate a role for the renin-angiotensin system in the cardiac hypertrophy that develops in response to pressure overload. The presence and chamber localization of angiotensinogen mRNA was determined using Northern hybridization and S1 nuclease mapping analysis. Angiotensinogen mRNA, as determined by dot-blot hybridization analysis, was significantly increased in hypertrophied left ventricles at both 7 and 15 days after the surgery, when compared with sham-operated controls. The activity of the circulating renin-angiotensin system, as indexed by plasma renin activity was increased at 1 day following surgery [6.0 +/- 2.0 ng.ml-1.h-1 angiotensin I (control) vs. 41.8 +/- 10.9 ng.ml-1.h-1 angiotensin I (experimental)], but returned to control values by day 3 postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K M Baker; M I Chernin; S K Wixson; J F Aceto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  259     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-14     Completed Date:  1990-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H324-32     Citation Subset:  IM    
Affiliation:
Weis Center for Research, Geisinger Clinic, Danville 17822.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Angiotensinogen / genetics
Animals
Aorta
Cardiomegaly / etiology*
Constriction, Pathologic
Enalapril / pharmacology
Hypertension / complications*
Kidney / metabolism
Male
Myocardium / metabolism
RNA, Messenger / metabolism
Rats
Rats, Inbred Strains
Renin / genetics
Renin-Angiotensin System*
Up-Regulation
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/RNA, Messenger; 11002-13-4/Angiotensinogen; 75847-73-3/Enalapril; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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