Document Detail

Renin-angiotensin system dysregulation in fetuses with hydronephrosis.
MedLine Citation:
PMID:  20236752     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate if fetal hydronephrosis is associated with dysregulation of the renin-angiotensin system (RAS), and if it could represent an early predictor of future renal damage or arterial hypertension. STUDY DESIGN: The study consisted of 26 pregnant women and their fetuses. Ultrasound scans were performed to evaluate the renal pelvis in fetuses. Four fetuses with hydronephrosis were included in the study, while the rest were found to have normal renal pelvis. Active and inactive renin was calculated by IRMA method in fetal and maternal blood, during the second trimester of pregnancy. RESULTS: A comparison of plasma active and inactive renin levels was made between pregnant women and their fetuses, as well as between fetuses with and without hydronephrosis. Active and inactive renin levels obtained from fetuses with hydronephrosis were significantly higher compared to those obtained from fetuses with normal kidneys. CONCLUSIONS: Dilatation of renal pelvis in the second trimester of pregnancy seems to up-regulate the renin and prorenin system in fetal blood. Both factors are indicative of possible future renal pathology.
Aikaterini Stipsanelli; George Daskalakis; Panagiota Koutra; Angeliki Tsaroucha; Evangelia Kounadi; Vassilios Papantoniou; Aris Antsaklis
Publication Detail:
Type:  Journal Article     Date:  2010-03-16
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  150     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Nuclear Medicine, Alexandra Maternity Hospital, Athens University, 80 Vas Sophias Av, Athens 115 28, Greece.
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MeSH Terms
Fetal Blood / chemistry
Hydronephrosis / physiopathology*,  ultrasonography
Infant, Newborn
Kidney / ultrasonography
Pregnancy Trimester, Second
Renin / blood*
Renin-Angiotensin System / physiology*
Ultrasonography, Prenatal
Reg. No./Substance:

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