| Renin-angiotensin system dysregulation in fetuses with hydronephrosis. | |
| | |
MedLine Citation:
|
PMID: 20236752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To evaluate if fetal hydronephrosis is associated with dysregulation of the renin-angiotensin system (RAS), and if it could represent an early predictor of future renal damage or arterial hypertension. STUDY DESIGN: The study consisted of 26 pregnant women and their fetuses. Ultrasound scans were performed to evaluate the renal pelvis in fetuses. Four fetuses with hydronephrosis were included in the study, while the rest were found to have normal renal pelvis. Active and inactive renin was calculated by IRMA method in fetal and maternal blood, during the second trimester of pregnancy. RESULTS: A comparison of plasma active and inactive renin levels was made between pregnant women and their fetuses, as well as between fetuses with and without hydronephrosis. Active and inactive renin levels obtained from fetuses with hydronephrosis were significantly higher compared to those obtained from fetuses with normal kidneys. CONCLUSIONS: Dilatation of renal pelvis in the second trimester of pregnancy seems to up-regulate the renin and prorenin system in fetal blood. Both factors are indicative of possible future renal pathology. |
| | |
Authors:
|
Aikaterini Stipsanelli; George Daskalakis; Panagiota Koutra; Angeliki Tsaroucha; Evangelia Kounadi; Vassilios Papantoniou; Aris Antsaklis |
Publication Detail:
|
Type: Journal Article Date: 2010-03-16 |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 150 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-12 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 39-41 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Nuclear Medicine, Alexandra Maternity Hospital, Athens University, 80 Vas Sophias Av, Athens 115 28, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Female Fetal Blood / chemistry Humans Hydronephrosis / physiopathology*, ultrasonography Infant, Newborn Kidney / ultrasonography Male Pregnancy Pregnancy Trimester, Second Renin / blood* Renin-Angiotensin System / physiology* Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnosis and management of adult female stress urinary incontinence: guidelines for clinical practi...
Next Document: Geometrical, conformational and topological restraints in regular nucleosome compaction in chromatin...