Document Detail

Renin-angiotensin system components and endothelial proteins as markers of diabetic microvascular disease.
MedLine Citation:
PMID:  8518538     Owner:  NLM     Status:  MEDLINE    
Endothelial cell damage, which is associated with local thrombin formation and inflammation, can lead to the release of endothelium-synthesized factors into plasma, such as vWFAg, TM, ACE and ET-1. These markers of endothelial damage are increased in some patients with diabetes mellitus, but the differences with normal are often small and not closely correlated with the severity of microvascular disease, as judged from the degree of albuminuria and the severity of retinopathy. Prorenin, which may also be related to abnormal endothelial cell function or endothelial damage, is elevated in many patients with diabetes, both type I and II, and its level is more closely correlated with the severity of microvascular disease. It is already elevated at an early stage. Further studies will reveal whether, in diabetes, an increased plasma prorenin is a reliable predictor of progressive microvascular disease. It is even conceivable that prorenin is not only a marker of diabetic microvascular disease but also has a role in its pathogenesis, via local proteolytic or non-proteolytic prorenin activation.
M A Schalekamp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Clinical investigator     Volume:  71     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1993  
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S3-6     Citation Subset:  IM    
Department of Internal Medicine I, University Hospital Dijkzigt, Rotterdam.
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MeSH Terms
Biological Markers / blood
Diabetic Angiopathies / blood*,  enzymology
Endothelium, Vascular / secretion*
Enzyme Precursors / blood
Renin / blood
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Enzyme Precursors; EC

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