Document Detail


Renin and angiotensin-converting enzyme genotypes in patients with essential hypertension and left ventricular hypertrophy.
MedLine Citation:
PMID:  8076423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The associations between left ventricular hypertrophy (LVH) and specific alleles of the renin and angiotensin-converting enzyme (ACE) genes were studied in patients with essential hypertension and normal blood pressure. 2. LVH was present in 42% of those with essential hypertension (n = 72) and 17% of those with normal blood pressure (n = 44). 3. The frequency of each renin allele was the same in hypertensive and in normotensive patients. Renin allele frequencies were also the same for those with LVH and those with normal cardiac mass. When only hypertensives were considered, renin alleles were in the same proportion for the groups with and without LVH. Similarly, ACE alleles were not associated with essential hypertension nor with elevated cardiac mass. 4. We conclude that, in this population, variations in the renin or ACE genes do not contribute significantly to the development of LVH or to essential hypertension.
Authors:
M J West; K M Summers; D J Burstow; K K Wong; P R Huggard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  21     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-10-06     Completed Date:  1994-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  207-10     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Queensland, Prince Charles Hospital, Brisbane, Australia.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Blood Pressure / physiology
Genotype
Humans
Hypertension / complications,  enzymology,  genetics*
Hypertrophy, Left Ventricular / complications,  enzymology,  genetics*
Peptidyl-Dipeptidase A / genetics*
Renin / genetics*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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