| Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke). | |
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MedLine Citation:
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PMID: 7473515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin-aldosterone hormonal servo-control system plays a major role in defending normotension and sodium and potassium balance. Derangements of the system involving either excess renin-angiotensin vasoconstriction or too much sodium-volume retention for the plasma-renin level can be implicated in sustaining the hypertension of most human hypertensive disorders. When plasma renin levels are inappropriately or inordinately increased, ischemic vascular injury to the heart, brain and kidneys becomes increasingly evident. In this setting, pharmacologic suppression or blockade of plasma renin activity protects from further cardiovascular damage in experimental models, in human hypertensive disorders and in human congestive heart failure. Still other studies suggest that excessive plasma prorenin levels may be involved in the vasodilator hyperperfusion vascular injury of diabetes mellitus. Recent findings provide considerable promise for pharmacologic strategies that suppress or block plasma renin activity in patients with hypertension or with congestive heart failure for achieving long-term protection from the major cardiovascular sequellae that shorten useful life. Future research to define better the factors that control renal renin gene expression and renal renin secretion could lead to even better treatment and prevention strategies. |
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Authors:
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J H Laragh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of human hypertension Volume: 9 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-11-30 Completed Date: 1995-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 385-90 Citation Subset: IM |
Affiliation:
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Cardiovascular Center, New York Hospital-Cornell University Medical Center, NY 11021, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology* Animals Blood Pressure / physiology* Cardiovascular Diseases / etiology, physiopathology* Cerebrovascular Disorders / complications Electrolytes / metabolism* Heart Failure / physiopathology Homeostasis Humans Hypertension / physiopathology Myocardial Infarction / complications Renin-Angiotensin System / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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