Document Detail


Renin-angiotensin and adrenergic mechanisms in control of blood pressure in fowl.
MedLine Citation:
PMID:  6266958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many avian species demonstrate atherosclerosis and high blood pressure (BP) that are influenced by age, sex, diet, and environment, but show no arteriosclerosis in small vessels. Thus, we aimed to define neural and humoral control of BP in conscious, 32-wk-old female chickens, Gallus gallus. Mean aortic pressure (determined by chronically implanted catheter) was 137.6 +/- 2.0 mm Hg; heart rate was 295 +/- 4 beats/min. Plasma renin activity (PRA), measured by radioimmunoassay of fowl angiotensin I ([Asp1, Val5, Ser9]AI), and plasma angiotensinogen levels were 3.55 +/- 0.31 ng/ml/hr and 1229 +/- 66 ng/ml respectively. Repeated injection of propranolol (4 to 8 mg/kg/day, i.m.) decreased (p less than 0.01) the BP 19.1 +/- 3.0 mm Hg and heart rate 76 +/- 6 beats/min. Acute infusion of propranolol also markedly reduced BP and heart rate, and increased plasma levels of norepinephrine and epinephrine. SQ 14,225 (20 mg/kg/day) reduced BP (p less than 0.01), but BP returned towards original levels unless a higher dose was given. PRA increased 2- to 6-fold. BP also decreased 31.0 +/- 2.1 mm Hg after reserpine treatment, but not after [Sar1, Ile8]AII. These results suggest that in maintaining BP in fowl the beta-adrenergic function is important, whereas the renin-angiotensin system may not have a primary role.
Authors:
H Nishimura; Y Nakamura; A A Taylor; M A Madey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  3     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1981 May-Jun
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I41-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
1-Sarcosine-8-Isoleucine Angiotensin II / pharmacology
Angiotensins / physiology*
Animals
Blood Pressure* / drug effects
Captopril / pharmacology
Chickens / physiology*
Electrolytes / blood
Female
Propranolol / pharmacology
Receptors, Adrenergic / physiology*
Receptors, Adrenergic, beta / physiology*
Renin / physiology*
Reserpine / pharmacology
Grant Support
ID/Acronym/Agency:
AM-17824/AM/NIADDK NIH HHS; HLB-22674/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensins; 0/Electrolytes; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 50-55-5/Reserpine; 525-66-6/Propranolol; 62571-86-2/Captopril; 9088-01-1/1-Sarcosine-8-Isoleucine Angiotensin II; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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