Document Detail

Renin Angiotensin Antagonists Normalize Aberrant Activation of Epithelial Sodium Channels in Sodium-Sensitive Hypertension.
MedLine Citation:
PMID:  23594971     Owner:  NLM     Status:  Publisher    
Epithelial sodium channels (ENaC) are ion transporters in the aldosterone-sensitive distal nephron that play an important role in sodium reabsorption in the terminal nephron. Our study of inbred C57Bl6/J mice given a high-sodium diet showed increased ENaC expression accompanied by tubular renin activation on qRT-PCR of laser-captured tubule specimens and Western blotting of membrane proteins, despite inhibition of aldosterone. Treatment with an angiotensin-converting-enzyme inhibitor (ACEI) or an angiotensin receptor blocker (ARB) effectively lowered blood pressure. In addition to lowering blood pressure, ACEI and ARB inhibition downregulated ENaC and renin expression in renal tubules. These effects would act to suppress sodium reabsorption via ENaC and normalize molecular mechanisms that elevate blood pressure in response to increased salt intake.
Hisako Ushio-Yamana; Shintaro Minegishi; Tomoaki Ishigami; Naomi Araki; Masanari Umemura; Koichi Tamura; Emi Maeda; Yutaka Kakizoe; Kenichiro Kitamura; Satoshi Umemura
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-09
Journal Detail:
Title:  Nephron. Experimental nephrology     Volume:  122     ISSN:  1660-2129     ISO Abbreviation:  Nephron Exp. Nephrol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159770     Medline TA:  Nephron Exp Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  95-102     Citation Subset:  -    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Department of Medical Science and Cardio-Renal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
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