Document Detail

Renewing the assault on mRNA.
MedLine Citation:
PMID:  23372488     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Mammalian cells dislike double-stranded RNA. They interpret it as a sign of an intruder, and they can unleash a recently discovered defensive mechanism to deal with the problem - they chop the invader into little pieces and use the remnants, called small interfering RNA, to identify and destroy the invader and its progeny. This process, known as RNA interference, may lend itself to new treatments for a wide range of diseases. RNA interference, however, resembles two therapies studied during the 1990s, antisense and ribozymes, in that the gene-silencing target is messenger RNA (mRNA). Is RNA interference really the Next Big Thing - or just a variation on an older but still intriguing theme?
Jack McCain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biotechnology healthcare     Volume:  1     ISSN:  1554-169X     ISO Abbreviation:  Biotechnol Healthc     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-02-04     Revised Date:  2013-04-12    
Medline Journal Info:
Nlm Unique ID:  101241418     Medline TA:  Biotechnol Healthc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-53     Citation Subset:  -    
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