Document Detail


Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
MedLine Citation:
PMID:  15841207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ. For instance, it is the major source of circulating erythropoietin and renin. Despite currently available therapies, there is a marked increase in cardiovascular morbidity and mortality among patients suffering from end-stage renal disease. We hypothesized that the current understanding of the endocrine function of the kidney was incomplete and that the organ might secrete additional proteins with important biological roles. Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). In humans, renalase gene expression is highest in the kidney but is also detectable in the heart, skeletal muscle, and the small intestine. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. Renalase infusion in rats caused a decrease in cardiac contractility, heart rate, and blood pressure and prevented a compensatory increase in peripheral vascular tone. These results identify renalase as what we believe to be a novel amine oxidase that is secreted by the kidney, circulates in blood, and modulates cardiac function and systemic blood pressure.
Authors:
Jianchao Xu; Guoyong Li; Peili Wang; Heino Velazquez; Xiaoqiang Yao; Yanyan Li; Yanling Wu; Aldo Peixoto; Susan Crowley; Gary V Desir
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2005-04-07
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  115     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-07-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1275-80     Citation Subset:  AIM; IM    
Affiliation:
Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. jianchao.xu@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / genetics,  physiology*
Humans
Kidney / enzymology
Liver / enzymology
Monoamine Oxidase / genetics,  isolation & purification,  metabolism*
Muscle, Skeletal / enzymology
Myocardium / enzymology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DK02917/DK/NIDDK NIH HHS; DK064317/DK/NIDDK NIH HHS; DK48105B/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
EC 1.4.3.4/Monoamine Oxidase
Comments/Corrections

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