| Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. | |
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MedLine Citation:
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PMID: 18277152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Recent experimental data shed light on the regulation of renalase, a secreted amine oxidase, which circulates in an inactive form (prorenalase). Abnormalities in the renalase pathway are evident not only in animal models of chronic kidney disease, but also during the development of hypertension, at a time when kidney function appears normal. RECENT FINDINGS: Prorenalase is rapidly (30-60 s) activated by increased plasma catecholamines and systolic blood pressure. Catecholamine administration promotes the secretion of preformed renalase within 5 min. Plasma renalase is markedly reduced in patients with chronic kidney disease and end-stage renal disease, and in animal models of chronic kidney disease and salt-dependent hypertension. Rats subjected to subtotal nephrectomy develop hypertension and chronic kidney disease, and exhibit low plasma and cardiac renalase, and abnormal renalase activation. SUMMARY: The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, cardiac function and blood pressure. In this pathway, prorenalase is rapidly activated by increased catecholamines and converted to renalase, which in turn degrades catecholamines. Abnormalities in the renalase pathway are evident in animal models of chronic kidney disease and hypertension. Collectively, these data suggest that renalase plays a key role in the regulation of sympathetic tone, blood pressure and cardiac function. |
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Authors:
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Gary V Desir |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 17 ISSN: 1062-4821 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-06-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 181-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8029, USA. gary.desir@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cardiovascular Diseases / enzymology, etiology*, physiopathology Catecholamines / blood Chronic Disease Disease Models, Animal Enzyme Activation Enzyme Precursors / blood, deficiency* Humans Hypertension / enzymology, etiology*, physiopathology Kidney / enzymology* Kidney Diseases / complications, enzymology*, physiopathology Monoamine Oxidase / blood, deficiency* |
| Grant Support | |
ID/Acronym/Agency:
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DK48105B/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Enzyme Precursors; EC 1.4.3.4/Monoamine Oxidase; EC 1.4.3.4./renalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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