Document Detail

Renal vein renins: inability to predict response to revascularization in patients with hypertension.
MedLine Citation:
PMID:  1994424     Owner:  NLM     Status:  MEDLINE    
To determine whether the captopril-stimulated renal vein renin ratio (CSRVRR) could enable identification of patients with hemodynamically significant renovascular lesions who would respond to revascularization, the authors measured CSRVRRs in 143 consecutive patients with hypertension who had been selected because of clinical features suggestive of renovascular hypertension. All patients underwent conventional renal arteriography. Renovascular hypertension was the final diagnosis if revascularization resulted in cure or improvement in blood pressure. Complete data were available for 133 patients. Twenty patients had renovascular hypertension; CSRVRR was greater than 1.5 in 13 of these 20 patients (sensitivity, 65%). However, it was also greater than 1.5 in 54 of the 113 patients without renovascular hypertension (false-positive rate, 47.8%). The positive predictive value of CSRVRR was 18.6%; the negative predictive value, 89.3%. It is concluded that CSRVRR is not sufficiently sensitive to enable prediction of which patients will respond to revascularization and is not specific enough to exclude patients who do not have renovascular hypertension.
M A Roubidoux; N R Dunnick; P E Klotman; G E Newman; R H Cohan; S Kadir; L P Svetkey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  178     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-03-21     Completed Date:  1991-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  819-22     Citation Subset:  AIM; IM    
Department of Radiology, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Captopril / diagnostic use
Clinical Enzyme Tests*
Hypertension, Renovascular / diagnosis*,  epidemiology,  therapy
Middle Aged
Predictive Value of Tests
Prospective Studies
Renal Veins*
Renin / blood*
Sensitivity and Specificity
Grant Support
Reg. No./Substance:
62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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