Document Detail

Renal vascular lesions after chemotherapy with vinblastine, bleomycin, and cisplatin.
MedLine Citation:
PMID:  6181679     Owner:  NLM     Status:  MEDLINE    
A 30 year old man with metastatic embryonal carcinoma became hypertensive during vinblastine, bleomycin, and cisplatin therapy. Three months after completion of therapy, accelerated hypertension occurred (blood pressure 210/140 mm Hg). Nitroprusside failed to control the hypertension, but captopril resulted in a prompt and sustained normalization of the blood pressure. The plasma renin activity was markedly elevated before therapy. Renal biopsy disclosed "onionskin" narrowing of the interlobular arteries and fibrin thrombosis of a majority of the afferent arterioles. A form of drug-induced renovascular hypertension is suggested.
R M Harrell; R Sibley; N J Vogelzang
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  73     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-33     Citation Subset:  AIM; IM    
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MeSH Terms
Bleomycin / adverse effects*
Captopril / therapeutic use
Cisplatin / adverse effects*
Drug Therapy, Combination
Hypertension, Renovascular / chemically induced,  drug therapy
Kidney / pathology
Kidney Diseases / chemically induced,  pathology
Renal Artery Obstruction / chemically induced*
Testicular Neoplasms / drug therapy
Vinblastine / adverse effects*
Grant Support
Reg. No./Substance:
11056-06-7/Bleomycin; 15663-27-1/Cisplatin; 62571-86-2/Captopril; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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