| Renal tubular defects from antidepressant use in an older adult: An uncommon but reversible adverse drug effect. | |
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MedLine Citation:
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PMID: 17163295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adverse drug reactions are common and contribute to significant mortality and morbidity. We report a case study of an elderly woman who manifested with uncommon reversible renal tubular defects following the use of escitalopram. She was initially seen for worsening symptoms of depression and started on escitalopram in addition to her regular medications, which included donepezil, hydrochlorothiazide and mirtazapine. Three weeks later, she became increasingly confused and manifested recurrent falls. Laboratory evaluation showed hyponatraemia and evidence of renal tubular absorption defects. The patient's symptoms and laboratory abnormalities improved upon discontinuation of escitalopram as well as of mirtazapine and hydrochlorthiazide. This case illustrates the possibility of rare but reversible renal tubular defects associated with the use of antidepressant medications. |
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Authors:
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Giridhar U Adiga; T S Dharmarajan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical drug investigation Volume: 26 ISSN: 1173-2563 ISO Abbreviation: Clin Drug Investig Publication Date: 2006 |
Date Detail:
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Created Date: 2006-12-13 Completed Date: 2007-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504817 Medline TA: Clin Drug Investig Country: New Zealand |
Other Details:
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Languages: eng Pagination: 607-10 Citation Subset: IM |
Affiliation:
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Halifax Regional Medical Center, Roanoke Rapids, North Carolina 27870, USA. adiga69@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antidepressive Agents, Second-Generation / adverse effects* Citalopram / adverse effects* Female Humans Inappropriate ADH Syndrome / chemically induced Kidney Tubules / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 59729-33-8/Citalopram |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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