Document Detail

Renal tubular defects from antidepressant use in an older adult: An uncommon but reversible adverse drug effect.
MedLine Citation:
PMID:  17163295     Owner:  NLM     Status:  MEDLINE    
Adverse drug reactions are common and contribute to significant mortality and morbidity. We report a case study of an elderly woman who manifested with uncommon reversible renal tubular defects following the use of escitalopram. She was initially seen for worsening symptoms of depression and started on escitalopram in addition to her regular medications, which included donepezil, hydrochlorothiazide and mirtazapine. Three weeks later, she became increasingly confused and manifested recurrent falls. Laboratory evaluation showed hyponatraemia and evidence of renal tubular absorption defects. The patient's symptoms and laboratory abnormalities improved upon discontinuation of escitalopram as well as of mirtazapine and hydrochlorthiazide. This case illustrates the possibility of rare but reversible renal tubular defects associated with the use of antidepressant medications.
Giridhar U Adiga; T S Dharmarajan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical drug investigation     Volume:  26     ISSN:  1173-2563     ISO Abbreviation:  Clin Drug Investig     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504817     Medline TA:  Clin Drug Investig     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  607-10     Citation Subset:  IM    
Halifax Regional Medical Center, Roanoke Rapids, North Carolina 27870, USA.
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MeSH Terms
Aged, 80 and over
Antidepressive Agents, Second-Generation / adverse effects*
Citalopram / adverse effects*
Inappropriate ADH Syndrome / chemically induced
Kidney Tubules / drug effects*
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 59729-33-8/Citalopram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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