Document Detail

Renal tubular calcium transport: effects of changes in filtered calcium load.
MedLine Citation:
PMID:  6624913     Owner:  NLM     Status:  MEDLINE    
Micropuncture experiments were performed in thyroparathyroidectomized dogs to examine the influence of changes in filtered calcium load on segmental tubular calcium reabsorption. Filtered calcium load was changed either by reducing glomerular filtration rate (GFR) by aortic clamping (group I) or by progressive calcium infusion (group II) to increase plasma ultrafilterable calcium concentration (UFCa). The results suggest that fractional proximal calcium reabsorption responds similarly to altered filtered load, whether produced by changes in GFR or UFCa. In contrast, fractional reabsorption by the loop segment is progressively reduced as UFCa is increased but is relatively unchanged by alterations in filtered load secondary to altered GFR. These data indicate a specific parathyroid hormone-independent reciprocal effect of UFCa on calcium reabsorption in the loop segment, which may be an important determinant of urinary calcium excretion.
R A Sutton; N L Wong; G A Quamme; J H Dirks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  245     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F515-20     Citation Subset:  IM; S    
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MeSH Terms
Calcium / metabolism*
Electrolytes / blood,  urine
Glomerular Filtration Rate
Kidney Tubules / physiology*
Kidney Tubules, Distal / physiology
Kidney Tubules, Proximal / physiology
Parathyroid Glands / physiology
Reg. No./Substance:
0/Electrolytes; 7440-70-2/Calcium

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