| Renal tubular acidosis secondary to capecitabine, oxaliplatin, and cetuximab treatment in a patient with metastatic colon carcinoma: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 20217448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of renal tubular acidosis (RTA) secondary to capecitabine, oxaliplatin, and cetuximab administration in a 63-year-old woman with liver metastasis from colon carcinoma who had partial treatment response. On day 5 posttreatment, she arrived to the emergency room with severe weakness, and blood tests demonstrated hypokalemia with metabolic acidosis. Urine potassium levels were elevated, and the transtubular potassium gradient (TTKG) was 6.6, consistent with hypokalemic RTA with associated Fanconi syndrome, which presented as hyperphosphaturia, uricaciduria, and loss of protein and sugar in the urine. She was treated with intravenously administered potassium and fluids. RTA is one type of nephrotoxicity induced by chemotherapy, and it is reversible in mild cases when appropriately treated. The mechanism of RTA induced by chemotherapy in cancer patients has not yet been clearly elucidated. Oncologists should therefore be aware of the potential for RTA to occur after capecitabine, oxaliplatin, and cetuximab treatment, especially in the context of other predisposing factors. |
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Authors:
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Amir Sonnenblick; Amichay Meirovitz |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-03-10 |
Journal Detail:
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Title: International journal of clinical oncology Volume: 15 ISSN: 1437-7772 ISO Abbreviation: Int. J. Clin. Oncol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-11-23 Revised Date: 2012-12-13 |
Medline Journal Info:
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Nlm Unique ID: 9616295 Medline TA: Int J Clin Oncol Country: Japan |
Other Details:
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Languages: eng Pagination: 420-2 Citation Subset: IM |
Affiliation:
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Oncology Department, Hadassah-Hebrew University Medical Center, Ein Kerem, POB 12000, 91120 Jerusalem, Israel. amirsonn@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Renal Tubular
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chemically induced*,
therapy Adenocarcinoma / drug therapy*, secondary, surgery Antibodies, Monoclonal / administration & dosage Antineoplastic Combined Chemotherapy Protocols / adverse effects* Chemotherapy, Adjuvant Colectomy Colonic Neoplasms / drug therapy*, pathology, surgery Deoxycytidine / administration & dosage, analogs & derivatives Female Fluid Therapy Fluorouracil / administration & dosage, analogs & derivatives Humans Liver Neoplasms / drug therapy*, secondary Middle Aged Organoplatinum Compounds / administration & dosage Potassium / administration & dosage Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Organoplatinum Compounds; 0/cetuximab; 154361-50-9/capecitabine; 51-21-8/Fluorouracil; 63121-00-6/oxaliplatin; 7440-09-7/Potassium; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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