Document Detail


Renal transplantation and secondary hyperparathyroidism.
MedLine Citation:
PMID:  9088065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secondary hyperparathyroidism (2'HPT) improves after renal transplantation (RTx) along with recovered function of the renal allograft. However, normal renal function does not last long due to rejection, drug-induced nephrotoxic nepthropathy, or recurrence of post-transplant glomerulonephritis. Therefore, improved calcium and phosphate metabolism, and parathyroid function after RTx fluctuate in accordance with the function of the renal allograft. In cases with severe 2'HPT, parathyroidectomy should be performed before RTx because hypercalcemia due to secondary or tertiary hyperparathyroidism aggravates the renal allograft function. In the follow-up of mild 2'HPT after RTx, hypercalcemia and vascular calcification should be monitored carefully by serum parathyroid hormone, calcium and phosphate concentrations, alkaline phosphatase activity, and bone X-ray film. If serum calcium level exceeds 12 mg/dl, parathyroidectomy (PTx) should be performed to prevent the acceleration of vascular calcification. Total PTx with forearm allograft is a preferred surgical procedure for 2'HPT even after RTx.
Authors:
K Uchida; Y Tominaga; Y Tanaka; H Takagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in surgical oncology     Volume:  13     ISSN:  8756-0437     ISO Abbreviation:  Semin Surg Oncol     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-05-27     Completed Date:  1997-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503713     Medline TA:  Semin Surg Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Affiliation:
Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Cholecalciferol / blood
Humans
Hypercalcemia
Hyperparathyroidism, Secondary / surgery*
Hypophosphatemia
Kidney Transplantation*
Parathyroid Hormone / blood
Parathyroidectomy
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 67-97-0/Cholecalciferol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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