Document Detail

Renal transplantation and red blood cell sodium transport: role of prednisone treatment.
MedLine Citation:
PMID:  1652707     Owner:  NLM     Status:  MEDLINE    
This study assesses the role of prednisone and endogenous digoxin-like immunoreactivity (EDLI) in the increased Na+ pump activity in renal allograft patients. Red blood cell (RBC) Na+ transport activities and plasma concentrations of EDLI were measured in ten controls and ten renal allograft recipients (5 hypertensive) while undergoing treatment with cyclosporin, prednisone, and azathioprine, and also after prednisone withdrawal. As compared to controls, prednisone-treated patients showed an increased Na+ pump activity (0.323/h vs 0.571, P less than 0.05) and decreased RBC Na+ concentration (6.69 mM vs 4.99, P less than 0.05). They also showed a decrease in the activity of cotransport, countertransport, and passive Na+ efflux (0.02/h vs 0.005, P less than 0.05; 207 mumol/l vs 35, P less than 0.05; 0.02/h vs 0.005 respectively, P less than 0.05). After prednisone withdrawal, normotensive and hypertensive patients showed RBC Na+ transport system activities and RBC Na+ concentration similar to those of controls. EDLI was not detected in controls or in patients. We conclude that prednisone treatment increased the Na+ pump activity, and decreased the RBC Na+ concentration. Moreover, it induced a decrease in the activity of secondary RBC Na+ transport systems. This study provides no evidence for a modulatory role of EDLI in the RBC Na+ pump activity. Neither parameters can be presumed to be a marker of hypertension in these patients.
R J Bosch; N Hernando; J J Plaza; S Casado; J M Lopez-Novoa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  6     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  286-91     Citation Subset:  IM    
Department of Nephrology, Fundación Jiménez Díaz-Consejo Superior de Investigaciones Científicas, Madrid, Spain.
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MeSH Terms
Biological Transport, Active
Blood Pressure / drug effects
Blood Proteins / physiology
Erythrocytes / drug effects,  metabolism
Kidney Transplantation / physiology*
Lithium / blood
Middle Aged
Potassium / blood
Prednisone / pharmacology*
Sodium / blood*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors,  blood
Reg. No./Substance:
0/Blood Proteins; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 53-03-2/Prednisone; 7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC ATPase
Comment In:
Nephrol Dial Transplant. 1992;7(2):175-6   [PMID:  1314982 ]

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