Document Detail

Renal transplantation in lupus nephritis.
MedLine Citation:
PMID:  15732296     Owner:  NLM     Status:  MEDLINE    
Most patients with systemic lupus erythematosus (SLE) are suitable candidates for renal transplantation. However, a number of them may present some disease-related problems. As cardiovascular disease is a leading cause of morbidity and mortality in SLE patients, a careful pretransplant cardiovascular screening is recommended. A search for antiphospholipid antibodies is also useful as the presence of these antibodies can cause an early graft thrombosis. The risk of recurrence of SLE nephritis after transplantation may range between 2 and 30%. In most cases recurrence is characterized by mild histologic lesions. Only rarely does it lead to graft failure. Postransplant immunosuppression does not differ from that used routinely. Whenever possible, a steroid-free immunosuppression should be scheduled to prevent iatrogenic toxicity in patients who have already received long-term steroid treatment. The results of kidney transplantation largely depend on the clinical conditions at transplantation. In patients with poor clinical status or receiving an aggressive immunosuppression it is advisable to postpone the transplant. When some selection criteria are respected, the results of renal trasplantation in SLE patients are at least as good as in other transplant recipients.
C Ponticelli; G Moroni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lupus     Volume:  14     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2005  
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
IRCCS Instituto Auxologicio, Milan, Italy.
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MeSH Terms
Antibodies, Antiphospholipid / immunology
Cardiovascular Diseases / complications,  drug therapy
Graft Rejection / etiology
Immunosuppressive Agents / therapeutic use
Kidney Transplantation*
Lupus Nephritis / complications,  immunology,  therapy*
Treatment Outcome
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Immunosuppressive Agents

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