| Renal transplant recipients and patients with end stage renal disease present with more advanced bladder cancer. | |
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MedLine Citation:
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PMID: 19683766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Renal transplant recipients have an increased incidence of bladder cancer. It is unknown whether these cancers are more aggressive than those in nontransplanted cases and whether this is also true for cases with end stage renal disease without renal transplantation. MATERIALS AND METHODS: Surveillance, Epidemiology and End Results-Medicare data identified 97,942 patients with bladder cancer diagnosed between 1988 and 2002. We compared gender, race, tumor stage and histology at diagnosis among patients with a renal transplant, end stage renal disease or neither condition. The statistical significance of differences in the distribution of patient and tumor variables was assessed using the chi-square statistic (categorical variables) and single factor ANOVA tests of difference in means (continuous variables). RESULTS: Renal transplant recipients (58) were younger at diagnosis than those with end stage renal disease (400) or with neither diagnosis (97,484) (p <0.0001). Muscle invasive disease (stage T2 or greater) at presentation was more common in renal transplant recipients (37%, p = 0.04) and patients with end stage renal disease (33%, p = 0.0001) than in patients without these conditions (24%). Most renal transplant recipients were diagnosed with bladder cancer within 4 years of transplantation. Patients with a renal transplant (17%, p = 0.001) and end stage renal disease (12%, p <0.0001) also had a higher proportion of nonurothelial tumors than the remaining population (6.5%). CONCLUSIONS: Renal transplant recipients and patients with end stage renal disease present with higher stage bladder cancer than those without these conditions despite closer medical supervision. Since most renal transplant recipients were diagnosed with bladder cancer within 4 years of undergoing renal transplantation, consideration should be given to bladder cancer screening of such patients in this period. |
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Authors:
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Behfar Ehdaie; George J Stukenborg; Dan Theodorescu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-15 |
Journal Detail:
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Title: The Journal of urology Volume: 182 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2009-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 1482-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, University of Virginia, Charlottesville, Virginia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Female Humans Kidney Failure, Chronic / complications*, surgery* Kidney Transplantation / adverse effects* Male Middle Aged Retrospective Studies Urinary Bladder Neoplasms / epidemiology, etiology*, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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CA104106/CA/NCI NIH HHS |
| Comments/Corrections | |
Comment In:
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J Urol. 2009 Oct;182(4):1487
[PMID:
19683768
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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