Document Detail


Renal sympathetic nerve ablation: the new frontier in the treatment of hypertension.
MedLine Citation:
PMID:  20425157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sympathetic nervous system plays an important role in circulatory and metabolic control and has clearly been established as a major contributor to the development of hypertension, as elevated sympathetic nerve activity initiates and sustains the elevation of blood pressure. Increased sympathetic outflow to the heart, resulting in increased cardiac output and neurally mediated vasoconstriction of peripheral blood vessels, is an obvious example of a neural pathophysiologic pathway leading to elevated blood pressure. The consequences of increased sympathetic outflow to the kidneys, perhaps most important in this context, are sodium and water retention, increased renin release, and alterations of renal blood flow-effects that contribute substantially to both acute and long-term blood pressure elevations. Accordingly, renal sympathetic nerve ablation appears to be a logical therapeutic approach for the treatment of hypertension. Recent reports on a novel catheter-based renal nerve ablation procedure reviewed in this article are promising.
Authors:
Markus P Schlaich; Henry Krum; Paul A Sobotka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  12     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Affiliation:
Neurovascular Hypertension & Kidney Disease Laboratory, Baker IDI Heart & Diabetes Institute, St. Kilda Road Central, Melbourne, Victoria 8008, Australia. markus.schlaich@bakeridi.edu.au
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / surgery
Animals
Blood Pressure / physiology*
Cardiovascular Diseases / epidemiology
Catheter Ablation*
Humans
Hypertension / epidemiology,  physiopathology,  surgery*
Kidney / innervation*
Kidney Failure, Chronic / epidemiology,  physiopathology
Norepinephrine / blood
Prognosis
Retrospective Studies
Sympathetic Nervous System / physiology,  surgery*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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