| Renal sympathetic nerve ablation: the new frontier in the treatment of hypertension. | |
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MedLine Citation:
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PMID: 20425157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sympathetic nervous system plays an important role in circulatory and metabolic control and has clearly been established as a major contributor to the development of hypertension, as elevated sympathetic nerve activity initiates and sustains the elevation of blood pressure. Increased sympathetic outflow to the heart, resulting in increased cardiac output and neurally mediated vasoconstriction of peripheral blood vessels, is an obvious example of a neural pathophysiologic pathway leading to elevated blood pressure. The consequences of increased sympathetic outflow to the kidneys, perhaps most important in this context, are sodium and water retention, increased renin release, and alterations of renal blood flow-effects that contribute substantially to both acute and long-term blood pressure elevations. Accordingly, renal sympathetic nerve ablation appears to be a logical therapeutic approach for the treatment of hypertension. Recent reports on a novel catheter-based renal nerve ablation procedure reviewed in this article are promising. |
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Authors:
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Markus P Schlaich; Henry Krum; Paul A Sobotka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 12 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 39-46 Citation Subset: IM |
Affiliation:
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Neurovascular Hypertension & Kidney Disease Laboratory, Baker IDI Heart & Diabetes Institute, St. Kilda Road Central, Melbourne, Victoria 8008, Australia. markus.schlaich@bakeridi.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways
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surgery Animals Blood Pressure / physiology* Cardiovascular Diseases / epidemiology Catheter Ablation* Humans Hypertension / epidemiology, physiopathology, surgery* Kidney / innervation* Kidney Failure, Chronic / epidemiology, physiopathology Norepinephrine / blood Prognosis Retrospective Studies Sympathetic Nervous System / physiology, surgery* |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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