| Renal sympathetic denervation in hypertension. | |
| | |
MedLine Citation:
|
PMID: 21885968 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Despite the abundance of antihypertensive drugs, resistant hypertension remains a major clinical problem. Recent technological advances render interventional management of resistant hypertension one of the hottest topics in the hypertension field. The aim of this review is to present the pathophysiologic background and the mechanisms mediating blood pressure reduction after renal sympathetic denervation, to analyze recent findings with this fascinating approach and to critically suggest future research directions. RECENT FINDINGS: Catheter-based, ablation-induced renal sympathetic denervation was initially studied in 45 patients with resistant hypertension in a proof-of-concept study. Impressive blood pressure reductions of about 30/15 mmHg were achieved at 6 months, without serious complications. A second, controlled, randomized (but not blinded) study confirmed the results, verifying the efficacy and safety of the procedure. A recent report revealed the 2-year durability of blood pressure reduction. SUMMARY: Data published so far indicate that ablation-induced renal denervation is a feasible, effective, and well tolerated interventional approach for the management of resistant hypertension. The groundbreaking studies of renal denervation in drug-resistant hypertension pave the way for further research in other disease conditions in which sympathetic overactivity seems to play a critical role. This initial wave of enthusiasm needs to be followed by rigorous investigation, for the proper identification of the potential and the limitations, indications, and contraindications of this approach. |
| | |
Authors:
|
Michael Doumas; Charles Faselis; Vasilios Papademetriou |
Related Documents
:
|
19187108 - Angiokeratoma-like changes in extragenital and genital lichen sclerosus. 20455998 - Small artery structure and function in hypertension. 10412418 - Structural changes in rat aortic intima due to transmural pressure. 16140248 - Effect of axial length on retinal vascular network geometry. 10694528 - Oscillatory patterns in sympathetic neural discharge and cardiovascular variables durin... 10793598 - Effect of cricoid pressure on insertion of and ventilation through the cuffed oropharyn... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-31 |
Journal Detail:
|
Title: Current opinion in nephrology and hypertension Volume: - ISSN: 1535-3842 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
aVeterans Affairs Medical Center - George Washington University bVeterans Affairs Medical Center - Georgetown University, Washington, DC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Urinary proteomics in the assessment of chronic kidney disease.
Next Document: Calcineurin inhibitors in kidney transplantation: friend or foe?