Document Detail


Renal sympathetic denervation as second line therapy in mild resistant hypertension - a pilot study.
MedLine Citation:
PMID:  22807098     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Catheter-based renal sympathetic denervation (CRD) is associated with significant blood pressure (BP) reductions in patients with severe therapy-resistant hypertension (office systolic BP = 160 mmHg or = 150 mmHg in diabetic patients). Effects of renal denervation on BP in patients with milder forms of therapy-resistant hypertension have not been examined. We sought to investigate the feasibility, safety and effectiveness of CRD in patients with longstanding mild hypertension despite treatment with = 3 antihypertensive drugs METHODS: Consecutive patients with office systolic BPs of 140-160 mmHg despite = 3 antihypertensive medications treated with CRD were included in this prospective study. Procedural safety and adverse events during follow-up were assessed. Clinical evaluations were performed at baseline, 3 and 6 months to determine changes in office systolic BPs, 24-h ambulatory BPs and medication doses RESULTS: Twenty patients (mean age 60.6 ± 10.8 years; 45% female) treated with an average of 5.4 ± 1.5 antihypertensive drugs were treated with CRD. The procedure was successful in all patients. There were no procedure- or device-related complications. BP at baseline was 148.4/83.0 ± 6.6/11.0 mmHg and decreased by 5.7/0.6 ± 20.0/8.3 mmHg (p=0.2) and 13.1/5.0 ± 13.6/8.3 mmHg (p<0.01) at 3 and 6 months respectively. Comparing baseline and 6-month follow-up, mean ambulatory 24 h-BP was reduced by 11.3/4.1 ± 8.6/7.3 mmHg (p<0.01). Four patients were able to reduce antihypertensive medications prior to their 3-month visit. © 2012 Wiley Periodicals, Inc.
Authors:
Benjamin Kaltenbach; Jennifer Franke; Stefan C Bertog; Daniel H Steinberg; Ilona Hofmann; Horst Sievert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
CardioVascular Center Frankfurt, Frankfurt am Main, Germany.
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