Document Detail

Renal sodium retention in cirrhosis: tubular site and relation to hepatic dysfunction.
MedLine Citation:
PMID:  3391509     Owner:  NLM     Status:  MEDLINE    
Renal sodium handling, assessed by the response to acute saline loading, was investigated in 14 well-compensated, nonascitic alcoholic cirrhotics and six normal controls. Urinary sodium excretion in cirrhotic patients (199 +/- 141 mumoles per min) was significantly lower than in controls (387 +/- 104 mumoles per min; p less than 0.01) at 3 hr postinfusion. In contrast to controls, renal plasma flow and glomerular filtration rate did not increase in the cirrhotics in response to acute saline loading. Proximal fractional reabsorption of sodium was estimated by clearance techniques in the presence of a hypotonic diuresis. Cirrhotic subjects with impaired functional liver cell mass as assessed by antipyrine clearance were unable to decrease proximal fractional reabsorption of sodium significantly in response to saline loading. Assessment in the cirrhotics included measurement of hepatic vein pressure gradient, indocyanine green extraction ratio, indocyanine green clearance, and antipyrine clearance as indices of portal pressure, intrahepatic shunting, hepatic blood flow and functional hepatocellular mass, respectively. Urinary sodium excretion in the cirrhotics correlated strongly with antipyrine clearance (r = 0.839, p less than 0.0001) and weakly with portal pressure (r = 0.562, p = 0.037). No correlation was seen with the other indices of hepatic blood flow and shunting. The findings of this study suggest that alcoholic cirrhosis is associated with a decline in hepatocellular function which results in either a decreased clearance of a salt-retaining hormone or decreased synthesis of a natriuretic hormone.(ABSTRACT TRUNCATED AT 250 WORDS)
L J Wood; D Massie; A J McLean; F J Dudley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  8     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1988-08-25     Completed Date:  1988-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-6     Citation Subset:  IM    
Gastroenterology Service, Alfred Hospital, Melbourne, Australia.
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MeSH Terms
Blood Pressure
Glomerular Filtration Rate
Hepatic Veins / physiopathology
Kidney / physiopathology*
Kidney Tubules / physiopathology
Liver / physiopathology
Liver Cirrhosis, Alcoholic / blood,  physiopathology*,  urine
Liver Function Tests
Middle Aged
Renal Circulation
Sodium / urine*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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