| Renal sodium retention in cirrhosis: tubular site and relation to hepatic dysfunction. | |
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MedLine Citation:
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PMID: 3391509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal sodium handling, assessed by the response to acute saline loading, was investigated in 14 well-compensated, nonascitic alcoholic cirrhotics and six normal controls. Urinary sodium excretion in cirrhotic patients (199 +/- 141 mumoles per min) was significantly lower than in controls (387 +/- 104 mumoles per min; p less than 0.01) at 3 hr postinfusion. In contrast to controls, renal plasma flow and glomerular filtration rate did not increase in the cirrhotics in response to acute saline loading. Proximal fractional reabsorption of sodium was estimated by clearance techniques in the presence of a hypotonic diuresis. Cirrhotic subjects with impaired functional liver cell mass as assessed by antipyrine clearance were unable to decrease proximal fractional reabsorption of sodium significantly in response to saline loading. Assessment in the cirrhotics included measurement of hepatic vein pressure gradient, indocyanine green extraction ratio, indocyanine green clearance, and antipyrine clearance as indices of portal pressure, intrahepatic shunting, hepatic blood flow and functional hepatocellular mass, respectively. Urinary sodium excretion in the cirrhotics correlated strongly with antipyrine clearance (r = 0.839, p less than 0.0001) and weakly with portal pressure (r = 0.562, p = 0.037). No correlation was seen with the other indices of hepatic blood flow and shunting. The findings of this study suggest that alcoholic cirrhosis is associated with a decline in hepatocellular function which results in either a decreased clearance of a salt-retaining hormone or decreased synthesis of a natriuretic hormone.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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L J Wood; D Massie; A J McLean; F J Dudley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 8 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1988 Jul-Aug |
Date Detail:
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Created Date: 1988-08-25 Completed Date: 1988-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 831-6 Citation Subset: IM |
Affiliation:
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Gastroenterology Service, Alfred Hospital, Melbourne, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Diuresis Female Glomerular Filtration Rate Hepatic Veins / physiopathology Humans Kidney / physiopathology* Kidney Tubules / physiopathology Liver / physiopathology Liver Cirrhosis, Alcoholic / blood, physiopathology*, urine Liver Function Tests Male Middle Aged Renal Circulation Sodium / urine* |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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