Document Detail

Renal sodium excretion in sons of hypertensive parents.
MedLine Citation:
PMID:  8349325     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate whether renal excretion of sodium is impaired and whether tubular reabsorption of sodium is increased in normotensive white men with a familial predisposition to develop essential hypertension. We compared 11 normotensive sons of two hypertensive parents (SOHT) with 11 normotensive sons of two normotensive parents (SONT); renal sodium handling was assessed after 1 week of low-sodium diet (10 mmol/d) and after 1 week of high-sodium diet (200 mmol/d). The SOHT were on average 5.5 years older than the SONT (46.9 +/- 5.2 [SD] vs 41.4 +/- 4.1, P = .012). On the sixth day of each diet, mean urinary sodium excretion did not differ between the two groups (12.9 +/- 6.3 vs 12.7 +/- 6.7 mmol/d on low-sodium diet, P = .930; 197 +/- 25 vs 200 +/- 27 mmol/d on high-sodium diet, P = .817). On the seventh day of each diet, baseline means for filtered load of sodium, absolute excretion of sodium, fractional excretion of sodium (an index of total tubular sodium reabsorption), and fractional excretion of lithium (an inverse index of proximal tubular sodium reabsorption) also did not differ between the groups. To assess renal sodium handling under non-steady-state conditions, we infused 2 L normal saline intravenously over a 2-hour period. The means for absolute excretion of sodium, fractional excretion of sodium, and fractional excretion of lithium increased from baseline, but the increases did not differ in magnitude between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
S T Turner; S L Reilly
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  22     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-09-16     Completed Date:  1993-09-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn. 55905.
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MeSH Terms
Blood Pressure*
Disease Susceptibility
Endothelins / blood
European Continental Ancestry Group
Kidney / secretion*
Middle Aged
Norepinephrine / urine
Sodium / urine*
Sodium Chloride / administration & dosage
Sodium, Dietary / administration & dosage
Grant Support
Reg. No./Substance:
0/Endothelins; 0/Sodium, Dietary; 51-41-2/Norepinephrine; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride

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