Document Detail


Renal side-effects of long-term lithium treatment.
MedLine Citation:
PMID:  9127825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The beta 2-Mg (beta 2-microglobulin) and GAG (glycosaminogyclan) excretions in 107 patients with bipolar disorder who had been on lithium treatment for 1-15 years were compared with 29 matched psychiatric control patients. 24-h urine volume, urine beta 2-Mg, GAG values were significantly higher, and maximal urinary osmolality was significantly lower in patients on lithium than in controls. No relationship was found between creatinine clearances and duration of illness, duration of lithium treatment and daily lithium dosages. Duration of lithium treatment was not related to the concentrating capacity. The beta 2-Mg excretion rates were significantly higher in patients with manifest polyuria and with severe concentration defect.
Authors:
H Coşkunol; S Vahip; E D Mees; A Başçi; O Bayindir; I Tuğlulaŕ
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of affective disorders     Volume:  43     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-23     Completed Date:  1997-07-23     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Basement Membrane / drug effects
Bipolar Disorder / drug therapy*,  urine
Creatinine / urine
Female
Glomerular Filtration Rate / drug effects
Glycosaminoglycans / urine
Humans
Kidney Concentrating Ability / drug effects
Kidney Function Tests*
Kidney Glomerulus / drug effects
Kidney Tubules, Proximal / drug effects
Lithium Chloride / administration & dosage,  adverse effects*
Long-Term Care
Male
Middle Aged
Polyuria / chemically induced*,  urine
beta 2-Microglobulin / urine
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/beta 2-Microglobulin; 60-27-5/Creatinine; 7447-41-8/Lithium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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