Document Detail

Renal safety of tenofovir disoproxil fumarate.
MedLine Citation:
PMID:  17323508     Owner:  NLM     Status:  MEDLINE    
Tenofovir disoproxil fumarate is approved to treat HIV infection in combination with other antiretroviral agents. Although tenofovir is generally well tolerated, the potential for nephrotoxicity exists based on preclinical data, case reports, and observational studies. Following its approval in the United States in October 2001, a series of case reports of tenofovir-related renal toxicity brought the issue to the attention of clinicians. While case reports raise the issue of nephrotoxicity, cohort studies and clinical trials have helped to clarify the overall safety profile of tenofovir. We present a review of the renal safety of tenofovir and provide a brief summary of the clinical implications of these data.
Paul E Sax; Joel E Gallant; Paul E Klotman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The AIDS reader     Volume:  17     ISSN:  1053-0894     ISO Abbreviation:  AIDS Read     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-03-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9206753     Medline TA:  AIDS Read     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-2, 99-104, C3     Citation Subset:  IM; X    
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MeSH Terms
Adenine / adverse effects,  analogs & derivatives*
Anti-HIV Agents / adverse effects*
Clinical Trials as Topic
HIV Infections / drug therapy*,  virology
Kidney / drug effects*
Kidney Diseases / chemically induced*
Phosphonic Acids / adverse effects*
Randomized Controlled Trials as Topic
Reverse Transcriptase Inhibitors / adverse effects*
Reg. No./Substance:
0/Anti-HIV Agents; 0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 73-24-5/Adenine
Comment In:
AIDS Read. 2007 Feb;17(2):102-3   [PMID:  17323509 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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