| Renal safety of tenofovir disoproxil fumarate. | |
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MedLine Citation:
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PMID: 17323508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tenofovir disoproxil fumarate is approved to treat HIV infection in combination with other antiretroviral agents. Although tenofovir is generally well tolerated, the potential for nephrotoxicity exists based on preclinical data, case reports, and observational studies. Following its approval in the United States in October 2001, a series of case reports of tenofovir-related renal toxicity brought the issue to the attention of clinicians. While case reports raise the issue of nephrotoxicity, cohort studies and clinical trials have helped to clarify the overall safety profile of tenofovir. We present a review of the renal safety of tenofovir and provide a brief summary of the clinical implications of these data. |
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Authors:
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Paul E Sax; Joel E Gallant; Paul E Klotman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The AIDS reader Volume: 17 ISSN: 1053-0894 ISO Abbreviation: AIDS Read Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-12 Completed Date: 2007-03-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206753 Medline TA: AIDS Read Country: United States |
Other Details:
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Languages: eng Pagination: 90-2, 99-104, C3 Citation Subset: IM; X |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
/
adverse effects,
analogs & derivatives* Anti-HIV Agents / adverse effects* Clinical Trials as Topic HIV Infections / drug therapy*, virology Humans Kidney / drug effects* Kidney Diseases / chemically induced* Phosphonic Acids / adverse effects* Randomized Controlled Trials as Topic Reverse Transcriptase Inhibitors / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 73-24-5/Adenine |
| Comments/Corrections | |
Comment In:
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AIDS Read. 2007 Feb;17(2):102-3
[PMID:
17323509
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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