Document Detail

Renal responses to chronic cold exposure.
MedLine Citation:
PMID:  12665254     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess our hypothesis that the release of antidiuretic hormone (ADH), the renal concentrating response to ADH, or both is decreased by prolonged cold exposure. Six groups (n = 6/group) of rats were used. Three groups were exposed to cold (5 degrees C), whilethe remaining three groups were kept at room temperature (25 degrees C). It was found that urine osmolality decreased significantly and serum osmolality increased significantly during cold exposure. The ratio of water/food intake was not affected by prolonged cold exposure. However, prolonged cold exposure increased the ratio of urine output/food intake in the cold-exposed rats, indicating that more urine flow is required by the cold-exposed rats to excrete the osmotic substance at a given food intake. The difference between water intake and urine output decreased significantly in the cold-exposed rats. Thus, prolonged cold exposure increases water loss from excretion. Renal concentrating responses to 24-h dehydration and Pitressin were decreased significantly in the cold-exposed rats. Plasma ADH levels remained unchanged, but renal ADH receptor (V2 receptor) mRNA was decreased significantly in the cold-exposed rats. The results strongly support the conclusion that cold exposure increases excretive water loss, and this may be due to suppression of renal V2 receptors rather than inhibition of ADH release.
Zhongjie Sun; Zhonge Zhang; Robert Cade
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  81     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-31     Completed Date:  2003-10-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
Department of Medicine, Box 100274, College of Medicine, University of Florida, Gainesville, FL 32610, U.S.A.
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MeSH Terms
Arginine Vasopressin / pharmacology
Body Water / physiology
Cold Temperature*
Kidney / drug effects,  physiology*
Osmolar Concentration
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Receptors, Vasopressin / genetics,  metabolism
Renal Agents / blood,  pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
Vasopressins / blood*
Water-Electrolyte Balance
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Vasopressin; 0/Renal Agents; 11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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