Document Detail

Renal responses of normal and preascitic broilers to systemic hypotension induced by unilateral pulmonary artery occlusion.
MedLine Citation:
PMID:  10626655     Owner:  NLM     Status:  MEDLINE    
During the pathophysiological progression of pulmonary hypertension syndrome (PHS; ascites), broilers concurrently develop systemic hypotension (low mean systemic arterial pressure) that may initiate renal retention of water and solute, contributing to fluid accumulation in the abdominal cavity (ascites). In male Single Comb White Leghorns, glomerular filtration is autoregulated over a systemic arterial pressure range of 110 to 60 mm Hg, and corresponding reductions in urine flow are attributed to a phenomenon known as pressure natriuresis. Acute unilateral pulmonary artery occlusion was used in the present study to reduce systemic arterial pressure toward the lower autoregulatory limit for glomerular filtration, and to evaluate kidney function in normal and preascitic broilers. Preascitic broilers characteristically exhibited lower (P < or = 0.05) values for mean systemic arterial pressure (91 vs 100 mm Hg) and percentage saturation of hemoglobin with oxygen (73 vs 84%), higher hematocrits (35 vs 30%), heavier right ventricles (3.44 vs 2.32 g), and higher right:total ventricular weight ratios (0.32 vs 0.24) than normal broilers. Body weights (2,445 vs 2,429 g, respectively), left ventricle plus septum weights (7.16 vs 7.19 g), and heart rates (349 vs 341 beats/min) were similar. Preascitic broilers exhibited larger (P < or = 0.05) dependent reductions in glomerular filtration, urine flow, osmolal clearance, and solute excretion and had a higher free water clearance than normal broilers in response to pulmonary artery occlusion. The differences observed between normal and preascitic broilers demonstrate that systemic hypotension can trigger renal mechanisms contributing to fluid and solute retention during development of PHS.
M F Forman; R F Wideman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  78     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1773-85     Citation Subset:  IM    
Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA.
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MeSH Terms
Ascites / physiopathology,  veterinary*
Glomerular Filtration Rate
Heart Ventricles / anatomy & histology
Hemoglobins / metabolism
Hypertension, Pulmonary / physiopathology,  veterinary
Hypotension / etiology,  physiopathology,  veterinary*
Kidney / physiopathology*
Organ Size
Osmolar Concentration
Oxygen / blood
Poultry Diseases / etiology,  physiopathology*
Pulmonary Artery*
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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