| Renal resistive index and nocturnal non-dipping: is there an association in essential hypertension? | |
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MedLine Citation:
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PMID: 18807207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal Doppler ultrasonography (RDU) is a useful method to determine renal resistive index (RRI). The RRI has been used to evaluate target organ damage (TOD) in essential hypertension. Nocturnal non-dipping of blood pressure (BP) in essential hypertension was also associated with TOD. The relationship between increased RRI and non-dipping has not been specifically studied before. Patients with newly diagnosed essential hypertension underwent 24-h ambulatory BP monitoring, biochemistry analysis, 24-h urine testing, and RDU. Totally, 198 patients (137 women, 61 men, aged 53.8 +/- 11.4 years) were included. Sixty-two patients were non-dippers, and 56 patients had increased RRI. RRI was increased in 32.3% of non-dipper patients and in 26.5% of dipper patients (P = 0.402). The RRIs of dippers were lower than the RRIs of non-dippers (0.65 +/- 0.06 vs. 0.68 +/- 0.07, P = 0.036). Multivariate logistic regression analysis of potential factors predicting increased RRI disclosed that advanced age (OR 1.090, CI 1.042-1.140, P < 0.0001) and increased pulse pressure (OR 1.037, CI 1.012-1.062, P = 0.004) were independently associated with increased RRI. In multivariate linear regression analysis, using the same independent variables, we found that square root-transformed RRI was independently associated with age (Beta + 0.366, P < 0.0001) and pulse pressure (Beta + 0.222, P = 0.001). Increased RRI and nocturnal non-dipping are not independently associated with each other in newly diagnosed essential hypertensive patients. Possible different mechanisms, or the same mechanisms but with different activation levels, may be responsible for the increased RRI and non-dipping as discrete pathologies. |
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Authors:
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Baris Afsar; Nurhan F Ozdemir; Rengin Elsurer; Siren Sezer |
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Publication Detail:
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Type: Journal Article Date: 2008-09-20 |
Journal Detail:
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Title: International urology and nephrology Volume: 41 ISSN: 1573-2584 ISO Abbreviation: Int Urol Nephrol Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-07 Completed Date: 2009-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 383-91 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Baskent University Hospital, 3. Cadde 50, Sokak 9/8, Bahcelievler, 06500 Ankara, Turkey. afsarbrs@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Blood Pressure Monitoring, Ambulatory Circadian Rhythm / physiology* Cohort Studies Cross-Sectional Studies Female Glomerular Filtration Rate Humans Hypertension / complications, physiopathology*, ultrasonography Male Middle Aged Renal Artery / physiopathology*, ultrasonography Risk Factors Ultrasonography, Doppler, Duplex Vascular Resistance / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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